We prove an inequality ofthe form fen a(lxl)7,-(dx) _> fen a(lxl)T,_ (dx), where Q is a bounded domain in R" with smooth boundary, B is a ball centered in the origin having the same measure as f. From this we derive inequalities comparing a weighted $obolev norm of a given function with the norm ofits symmetric decreasing rearrangement. Furthermore, we use the inequality to obtain comparison results for elliptic boundary value problems.