Uniquely different PVA-xanthan gum irradiated membranes as transdermal diltiazem delivery device

Bhunia, Tridib; Giri, Arindam; Nasim, Tanbir; Chattopadhyay, Dipankar; Bandyopadhyay, Abhijit

doi:10.1016/j.carbpol.2013.02.043

Cited by 39 publications

(18 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively xanthan gum can be modified by conventional chemical methods like carboxymethylation, and grafting such as free radical, microwave‐assisted, chemoenzymatic and plasma assisted chemical grafting . Table comprises examples of xanthan based systems used for the release of drugs, proteins or biosolutes. Each system has its intrinsic remarks because the interactions between polymeric matrix and released substance are controlled by medium ionic strength and pH, particularly in the case of xanthan, because changes in xanthan molecular conformation are also medium dependent.…”

Section: Xanthan Application For the Delivery Of Drugs Proteins Or Bmentioning

confidence: 99%

Xanthan gum: A versatile biopolymer for biomedical and technological applications

Petri

2015

J of Applied Polymer Sci

340

189

View full text Add to dashboard Cite

Xanthan gum is an extracellular polymer produced mainly by the bacterium Xanthomonas campestris. Traditionally it plays an important role in industrial applications as thickener, emulsion stabilizer and it has been added to water-based drilling fluids due to its pseudoplastic behavior and thermal stability. The structural properties of xanthan in solution can be tuned by the temperature and ionic strength; under high ionic strength or low temperature, xanthan chains are arranged in helical conformation, whereas under low ionic strength or high temperature, xanthan chains are coiled. Xanthan high molecular weight favors the building up of physical and chemical networks, which have been used as carriers for drugs and proteins and as scaffolds for cells. In combination with other polymers xanthan has been applied as excipient in tablets or as supporting hydrogels for drug release applications, particularly due to its acid resistance. The large versatility of xanthan gum opens the possibility for the creation of new architectures and additional applications involving this fascinating polymer. AIMSThe purpose of this review is to report on the applications of xanthan gum in biomedical and technological products over the last ten years, but revisiting the background and the highlights of traditional applications as thickener. The in vivo biodegradability and biocompatibility of xanthan gum are fundamental characteristics that allow its use in biomedical applications. The ability to form networks and acid resistance make xanthan gum, as pure excipient or in combination with other polymers, very attractive as drug carriers. The recent combinations with inorganic particles open a range of new applications.

show abstract

Section: Xanthan Application For the Delivery Of Drugs Proteins Or Bmentioning

confidence: 99%

Xanthan gum: A versatile biopolymer for biomedical and technological applications

Petri

2015

J of Applied Polymer Sci

340

189

View full text Add to dashboard Cite

show abstract

“…Trisaccharide side chains are composed of mannose, glucuronic acid and mannose linked by β-1,2 and β-1,4 glycosidic bond (Brunchi, 2016& Fitzpatrick, 2013.Approximately half of the terminal mannose residues are linked to pyruvic acid moieties by ketal linkage, while acetyl groups are often present as 6-O substituents on the internal mannose residues (Brunchi, 2016& Fitzpatrick, 2013.Xnt is used as thickening, suspending, and emulsifying agents in pharmaceutics (Karadağ, 2015& Davidson, 1980. It has been used in the hydrophilic matrix formulations for controlled drug release, and it also has applications as a supporting material in enzyme and cell immobilization (Karadağ, 2015;Bhunia, 2013;Bhattacharya, 2012;Alupei, 2002;García-Ochoa, 2000& Davidson, 1980. It was used in the preparation of a biodegradable hydrogels for skin scaffold (Juris, 2011).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Xanthan gum: Gelatin (Xnt:Gel) Hybrid Composite Hydrogels for Evaluating Skin Wound Healing Efficacy

Shawan¹,

Islam²,

Aziz³

et al. 2019

MAS

View full text Add to dashboard Cite

With the background of snowballing threat of skin wound to public health and economy, this study was undertaken utilizing xanthan gum (Xnt), citric acid (C), gelatin (Gel), glutaraldehyde (G) and HPLC-grade water to fabricate a series of composite hydrogels i.e. experimental rat skin wound model. Physicochemical characterization revealed that all the composite hydrogels contained more than 90% water. The hydrogels displayed swelling ability, biodegradability, good polymeric networks and porosity. Fourier Transform Infrared Spectroscopy (FT-IR) studies confirmed the presence of bound water and free, intra and inter molecular bound hydrogen bonded OH and NH in the hydrogels. All the hydrogels showed significant wound healing potency in experimental deep second degree skin burns in rats compared to controls.

show abstract

“…The XRD profiles of all the specimens were not dramatically changed after containing XG, indicating that the change in crystal structure is slightly affected by both XG inclusion and PVA concentration. It is known that XG in PVA can affect the viscosity of the specimens based on phase mixing and interaction which prevented the phase separation 13 . However, in this research, it is difficult to specify the relation between the viscosity change in the solutions and Young’s modulus of the specimens in this research.…”

Section: Discussionmentioning

confidence: 99%

Viscosity measurement of Xanthan–Poly(vinyl alcohol) mixture and its effect on the mechanical properties of the hydrogel for 3D modeling

Shimizu

Tanabe

Yoshida

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes require higher pressures than the upper pressure limit of the dispensers for pouring in high viscosity materials; the material viscosity should therefore be lower. Moreover, the mechanical properties of the biomodels should be reproduced. This study proposes a PVA solution through the addition of xanthan gum (XG) for 3D modeling, which lowers liquid viscosity while maintaining the mechanical properties of biomodels. XG is known to facilitate the achievement of non-Newtonian fluidity; however, the effects of XG on a PVA solution and PVA hydrogel (PVA-H) are not confirmed. The viscosity measurement using 15 wt% PVA with XG solution (PVA/XG) shows that it will provide easier pouring than 17 wt% PVA solution. The tensile test using the PVA-H of PVA(15 wt%)/XG(0.2 wt%) reveals that the gel is comparable in Young’s modulus to 17 wt% PVA-H. X-ray diffraction shows the crystalline structures of the PVA/XG gel and PVA-H are identical. Thus, this PVA/XG would be useful for fabricating biomodels using injection molding techniques.

show abstract

Uniquely different PVA-xanthan gum irradiated membranes as transdermal diltiazem delivery device

Cited by 39 publications

References 45 publications

Xanthan gum: A versatile biopolymer for biomedical and technological applications

Xanthan gum: A versatile biopolymer for biomedical and technological applications

Fabrication of Xanthan gum: Gelatin (Xnt:Gel) Hybrid Composite Hydrogels for Evaluating Skin Wound Healing Efficacy

Viscosity measurement of Xanthan–Poly(vinyl alcohol) mixture and its effect on the mechanical properties of the hydrogel for 3D modeling

Contact Info

Product

Resources

About