Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis

Jacobs, Brittany Y.; Dunnigan, K.; Pires-Fernandes, Margaret; Allen, Kyle D.

doi:10.1016/j.joca.2016.12.012

Cited by 28 publications

(26 citation statements)

References 31 publications

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“…Joint surfaces present many deep cracks and a very marked hypocellularity with cells having a very condensed appearance (arrows). (2020) 10:5277 | https://doi.org/10.1038/s41598-020-62146-0 www.nature.com/scientificreports www.nature.com/scientificreports/ In accordance with several previous studies [50][51][52][53] , we observed that MIA injection induced severe cartilage damage demonstrating that this method was effective to induce severe OA. Thus, as in human clinical cases, our rat model is suitable for total knee arthroplasty.…”

Section: Discussionsupporting

confidence: 90%

Total Knee Arthroplasty with a Ti6Al4V/PEEK Prosthesis on an Osteoarthritis Rat Model: Behavioral and Neurophysiological Analysis

Lecocq

Linares

Chaves‐Jacob

et al. 2020

Sci Rep

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Arthroplasty is a surgical procedure to restore the function of the joint of patient suffering from knee osteoarthritis. However, postoperative functional deficits are reported even after a rehabilitation program. In order to determine the origin of functional deficits of patient suffering from knee osteoarthritis and total knee arthroplasty, we developed a rodent model including a chemicallyinduced-osteoarthritis and designed a knee prosthesis (Ti6Al4V/PEEK) biomechanically and anatomically adapted to rat knee joint. Dynamic Weight-Bearing, gait kinematics, H-reflex from vastus medialis muscle and activities from metabosensitive III and IV afferent fibers in femoral nerve were assessed at 1 and 3 months post-surgery. Results indicate that knee osteoarthritis altered considerably the responses of afferent fibers to their known activators (i.e., lactic acid and potassium chloride) and consequently their ability to modulate the spinal sensorimotor loop, although, paradoxically, motor deficits seemed relatively light. On the contrary, results indicate that, after the total knee arthroplasty, the afferent responses and the sensorimotor function were slightly altered but that motor deficits were more severe. We conclude that neural changes attested by the recovery of the metabosensitive afferent activity and the sensorimotor loop were induced when a total knee replacement was performed and that these changes may disrupt or delay the locomotor recovery. Osteoarthritis (OA) is a common degenerative joint disease, characterized by a failure of cartilage self-repair. It originates from a stress occurring on the synovial joint tissues including joint cartilage, subchondral bone, ligaments, menisci, periarticular muscles, peripheral nerves or synovium and leads to inflammatory reaction 1-3. Mainly, OA involves hands and weight bearing joints, especially the knee which appears to be the most affected 4. The main symptoms of knee OA are pain and motor limitations related to joint deformity and weakness of surrounding muscles 1,5,6. When these symptoms become unsustainable, patients often resort to total knee arthroplasty (TKA) also called total knee replacement which is the gold standard treatment for end-stage knee OA.

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Section: Discussionsupporting

confidence: 90%

Total Knee Arthroplasty with a Ti6Al4V/PEEK Prosthesis on an Osteoarthritis Rat Model: Behavioral and Neurophysiological Analysis

Lecocq

Linares

Chaves‐Jacob

et al. 2020

Sci Rep

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“…This schematic shows a side view of EDGAR (A), floor design with instrumentation panels (B), and a single frame from a representative trial video (C). Image from Jacobs et al 58 .…”

Section: Resultsmentioning

confidence: 99%

“…This study points to the use of T1rho and T2 as noninvasive tools, which are sensitive to early changes in cartilage composition following meniscus injury. Jacobs et al 58 assessed differences in gait profiles of rats with medial meniscus transection (MMT) and monoiodoacetate (MIA) injection to simulate OA. The combined analysis of dynamic gait data with spatiotemporal data increased the sensitivity of detecting differences between the two OA models (Fig.…”

Section: Meniscus Injury and Oa Developmentmentioning

confidence: 99%

Osteoarthritis year in review 2018: mechanics

DeFrate

Kim-Wang

Englander

et al. 2019

Osteoarthritis and Cartilage

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Objective: To review recent biomechanics literature focused on the interactions between biomechanics and articular cartilage health, particularly focused on macro-scale and human studies. Design: A literature search was conducted in PubMed using the search terms (biomechanics AND osteoarthritis) OR (biomechanics AND cartilage) OR (mechanics AND osteoarthritis) OR (mechanics AND cartilage) for publications from April 2017 to April 2018. Results: Abstracts from the 559 articles generated from the literature search were reviewed. Due to the wide range of topics, 62 full texts with a focus on in vivo biomechanical studies were included for further discussion. Several overarching themes in the recent literature were identified and are summarized, including 1) new methods to detect early osteoarthritis (OA) development, 2) studies describing healthy and OA cartilage and biomechanics, 3) ACL injury and OA development, 4) meniscus injury and OA development, and 5) OA prevention, treatment, and management. Conclusions: Mechanical loading is a critical factor in the maintenance of joint health. Abnormal mechanical loading can lead to the onset and progression of OA. Thus, recent studies have utilized various biomechanical models to better describe the etiology of OA development and the subsequent effects of OA on the mechanics of joint tissues and whole body biomechanics.

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“…associated hardware and open-source analysis software were used to acquire spatiotemporal gait data [17,23,24] (additional information available online 1 ). Briefly, the arena is an enclosed, Fig.…”

Section: Spatiotemporal Gait Testing a Custom-built Gait Arena Withmentioning

confidence: 99%

“…Similar to grip strength, gait analysis has been used previously to quantify functional changes in rodent models of a variety of injury conditions including knee instability and osteoarthritis [15][16][17], patellar tendon degeneration [18], Achilles tendon injury [19], rotator cuff damage [20], and spinal cord injury [21]. Additionally, a recent study evaluated gait changes due to elbow contracture in a murine model [22]; however, in this study animals were only evaluated at a single time point for a single gait parameter.…”

Section: Introductionmentioning

confidence: 99%

Functional Measures of Grip Strength and Gait Remain Altered Long-Term in a Rat Model of Post-Traumatic Elbow Contracture

Reiter

Kivitz

Castile

et al. 2019

Journal of Biomechanical Engineering

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Post-traumatic joint contracture (PTJC) is a debilitating condition, particularly in the elbow. Previously, we established an animal model of elbow PTJC quantifying passive postmortem joint mechanics and histological changes temporally. These results showed persistent motion loss similar to what is experienced in humans. Functional assessment of PTJC in our model was not previously considered; however, these measures would provide a clinically relevant measure and would further validate our model by demonstrating persistently altered joint function. To this end, a custom bilateral grip strength device was developed, and a recently established open-source gait analysis system was used to quantify forelimb function in our unilateral injury model. In vivo joint function was shown to be altered long-term and never fully recover. Specifically, forelimb strength in the injured limbs showed persistent deficits at all time points; additionally, gait patterns remained imbalanced and asymmetric throughout the study (although a few gait parameters did return to near normal levels). A quantitative understanding of these longitudinal, functional disabilities further strengthens the clinical relevance of our rat PTJC model enabling assessment of the effectiveness of future interventions aimed at reducing or preventing PTJC.

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Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis

Cited by 28 publications

References 31 publications

Total Knee Arthroplasty with a Ti6Al4V/PEEK Prosthesis on an Osteoarthritis Rat Model: Behavioral and Neurophysiological Analysis

Total Knee Arthroplasty with a Ti6Al4V/PEEK Prosthesis on an Osteoarthritis Rat Model: Behavioral and Neurophysiological Analysis

Osteoarthritis year in review 2018: mechanics

Functional Measures of Grip Strength and Gait Remain Altered Long-Term in a Rat Model of Post-Traumatic Elbow Contracture

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