Unique skin abnormality in patients with peanut allergy but no atopic dermatitis

Berdyshev, Evgeny; Goleva, Elena; Bronoff, Anna-Sofia; Hoffman, Bryce; Ramirez-Gama, Marco; Garcia, Shannon; Crumrine, Debra; Elias, Peter M.; Cho, Christine B.; Leung, Donald Y.M.

doi:10.1016/j.jaci.2020.06.015

Cited by 14 publications

(5 citation statements)

References 25 publications

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“…A prior study elaborated that Peanut allergy was associated with reduced cis-UCA and PCA levels in the skin. 32 Both allantoic acid and PCA were substantially decreased on the surface of ulcers, which characterized lesions similar to other skin diseases. In addition, PCA has been reported to have immunomodulatory functions.…”

Section: Discussionmentioning

confidence: 97%

Analysis of Lower-Limb Ulcers in Participants with Leprosy Sequelae Using Metabolomics and 16S Ribosomal DNA Sequencing

Wang,

Liang

et al. 2023

CCID

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Purpose This study investigated microbiome and metabolome differences between ulcerated tissues and normal skin from the lower limbs of participants with leprosy. Patients and Methods Ulcerated tissues and surrounding normal skin were collected from the lower limbs of 28 participants with leprosy who had been cured. The 16S ribosomal DNA sequencing analysis of the samples was conducted with the Illumina NovaSeq platform to analyze the community structure and diversity of microorganisms on the skin surface, followed by non-targeted metabolomic analysis with LC-MS technology. Next, differential metabolites were statistically screened, followed by metabolic pathway analysis. The Spearman method was used to analyze the correlation between differential microbiota and differential metabolites. Results Compared to normal skin, ulcerated tissues showed a decrease in microbial α diversity (species richness, homogeneity, and sequencing depth), without significant differences (observed species, Chao1, Shannon, Simpson, and Pielou’s evenness index; P > 0.05). Conversely, Jaccard distance demonstrated that sample β-diversity exhibited a certain degree of clustering ( P < 0.05), with significant differences between the two groups. The results of LEfSe analysis revealed that compared to the normal skin, the ulcerated tissues had significantly decreased microbial abundance of Flavobacteriaceae, Flavobacteriales, Lachnospiraceae, Lachnospirales, Enterobacterales, Acinetobacter , and Moraxellaceae , which might be associated with the ulcerative state. The Spearman correlation analysis suggested a strong correlation between skin metabolome and skin microbiome. Conclusion For participants with leprosy sequelae, skin microecology and metabolites are disturbed and species diversity and homogeneity are reduced in lower-limb ulcers, and the types of skin metabolites are dependent on the microbiota.

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Section: Discussionmentioning

confidence: 97%

Analysis of Lower-Limb Ulcers in Participants with Leprosy Sequelae Using Metabolomics and 16S Ribosomal DNA Sequencing

Wang,

Liang

et al. 2023

CCID

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“…In the skin, peanut allergic children had lower levels of cis-UCA compared to non-atopic controls, independent of their atopic dermatitis. 54 Given these findings, the elevation of UCA in food allergic children in GACRS is unexpected, but may reflect differences between the isomers or between the plasma and skin metabolome.…”

Section: Altered Histidine Metabolism In Food Allergy and Oitmentioning

confidence: 96%

Metabolomics of IgE-Mediated Food Allergy and Oral Immunotherapy Outcomes based on Metabolomic Profiling

Virkud,

Styles,

Kelly

et al. 2024

Preprint

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BackgroundThe immunometabolic mechanisms underlying variable responses to oral immunotherapy (OIT) in patients with IgE-mediated food allergy are unknown.ObjectiveTo identify novel pathways associated with tolerance in food allergy, we used metabolomic profiling to find pathways important for food allergy in multi-ethnic cohorts and responses to OIT.MethodsUntargeted plasma metabolomics data were generated from the VDAART healthy infant cohort (N=384), a Costa Rican cohort of children with asthma (N=1040), and a peanut OIT trial (N=20) evaluating sustained unresponsiveness (SU, protection that lasts after therapy) versus transient desensitization (TD, protection that ends immediately afterwards). Generalized linear regression modeling and pathway enrichment analysis identified metabolites associated with food allergy and OIT outcomes.ResultsCompared with unaffected children, those with food allergy were more likely to have metabolomic profiles with altered histidines and increased bile acids. Eicosanoids (e.g., arachidonic acid derivatives) (q=2.4×10−20) and linoleic acid derivatives (q=3.8×10−5) pathways decreased over time on OIT. Comparing SU versus TD revealed differing concentrations of bile acids (q=4.1×10−8), eicosanoids (q=7.9×10−7), and histidine pathways (q=0.015). In particular, the bile acid lithocholate (4.97[1.93,16.14], p=0.0027), the eicosanoid leukotriene B4 (3.21[1.38,8.38], p=0.01), and the histidine metabolite urocanic acid (22.13[3.98,194.67], p=0.0015) were higher in SU.ConclusionsWe observed distinct profiles of bile acids, histidines, and eicosanoids that vary among patients with food allergy, over time on OIT and between SU and TD. Participants with SU had higher levels of metabolites such as lithocholate and urocanic acid, which have immunomodulatory roles in key T-cell subsets, suggesting potential mechanisms of tolerance in immunotherapy.Key Messages–Compared with unaffected controls, children with food allergy demonstrated higher levels of bile acids and distinct histidine/urocanic acid profiles, suggesting a potential role of these metabolites in food allergy.–In participants receiving oral immunotherapy for food allergy, those who were able to maintain tolerance-even after stopping therapyhad lower overall levels of bile acid and histidine metabolites, with the exception of lithocholic acid and urocanic acid, two metabolites that have roles in T cell differentiation that may increase the likelihood of remission in immunotherapy.Capsule summaryThis is the first study of plasma metabolomic profiles of responses to OIT in individuals with IgE-mediated food allergy. Identification of immunomodulatory metabolites in allergic tolerance may help identify mechanisms of tolerance and guide future therapeutic development.

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“…Badania przeprowadzono poprzez analizę słów kluczowych takich jak: "allergic march", "sublingual immunotherapy", "atopic dermatitis", "asthma". Ponadto wykazano, że osoby uczulone na orzeszki ziemne, bez współistniejącego AZS, mają mniejszą zawartość kwasu cis-urokanowego i kwasu piroglutaminowego w skórze, które to typowo są obecne w niezmienionej skórze pacjentów z AZS [5]. Obserwacje te sugerują, że pewne endotypy AZS mogą modyfikować progresję na marszu alergii.Pomimo że astma oraz katar sienny są często klinicznie powiązane, występowanie współistniejącego AZS, astmy i kataru siennego jest rzadko spotykane u dorosłych.…”

Section: Materiał I Metodyunclassified

Allergic march: a comprehensive approach to diagnosing, treating and preventing atopic diseases

Suwala,

Marchewka,

Bieńkowski

et al. 2023

J Educ Health Sport

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The article discusses the phenomenon of allergic march, which is a progressive process of atopic disease development in allergic patients. The inflammatory process changes localization, causing various symptoms such as atopic dermatitis, food allergy, asthma, allergic rhinitis and eosinophilic esophagitis. Allergic march has a major impact on the development of asthma and allergic rhinitis. The diversity of allergic march trajectories is due to the interaction of genetic, environmental and psychosocial factors. Understanding these mechanisms is crucial to prevent effectively the progression of allergic diseases. The article also discusses the advantages of sublingual immunotherapy (SILT) in the treatment of allergic diseases. SILT shows safety profile and may be more acceptable treatment option for the patients comparing to the traditional subcutaneous immunotherapy (SCIT). There are evidence of the beneficial effects of SILT in reducing allergy symptoms and improving quality of life in allergic patients.

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Unique skin abnormality in patients with peanut allergy but no atopic dermatitis

Cited by 14 publications

References 25 publications

Analysis of Lower-Limb Ulcers in Participants with Leprosy Sequelae Using Metabolomics and 16S Ribosomal DNA Sequencing

Analysis of Lower-Limb Ulcers in Participants with Leprosy Sequelae Using Metabolomics and 16S Ribosomal DNA Sequencing

Metabolomics of IgE-Mediated Food Allergy and Oral Immunotherapy Outcomes based on Metabolomic Profiling

Allergic march: a comprehensive approach to diagnosing, treating and preventing atopic diseases

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