Abstract:Chromosomal rearrangements involving the c-ros oncogene 1 ( ROS1) gene define a subset of non-small cell lung cancers highly sensitive to small-molecule tyrosine kinase inhibitors. However, little is known about the impact of different fusion partners on tyrosine kinase inhibitor efficacy. We herein describe a case of a 26-year-old never-smoker patient from southern Africa with metastatic lung adenocarcinoma driven by SLC12A2- ROS1 fusion, who had a pronounced and durable response to crizotinib. The present ca… Show more
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