Unique Effects of DDT and Other Chlorinated Hydrocarbons on the Metabolism of Formate and Proline in the Housefly^*

Metabolism in relation to mode of action of methylenedioxyphenyl synergists in houseflies

“…The distribution of radioactivity is practically identical following injection of labeled sodium formate or formaldehyde into houseflies. Injection of formate-C14 yields, among other radiolabeled compounds, proline, serine, glutamic acid, uric acid, and allantoin; eventually these compounds are excreted or become incorporated into fly tissues (Cline and Pearce, 1963;Gilmour, 1961). Less than 50% of the sodium formate-C14 injected into houseflies is expired as C1402; therefore, if formate-C14 is one of the intermediates in metabolism of M-C14-DP compounds in flies, the amount of C1402 expired from flies probably represents only a portion of the attack at the MDP moiety.…”