Abstract:It is well known that dogs suffer from at least two unusual traits related to Cu metabolism, which are (a) an inability of their serum albumin to bind Cu tightly, due to no histidine in the N terminal binding site; and (b) 10–20‐times higher liver Cu concentrations accompanied by a tendency to develop Cu overload.[1,2] We have identified and investigated two additional peculiarities in dogs related to components in their blood plasma. One has to do with ceruloplasmin (Cp), a 132 kDa glycoprotein, which has fun… Show more
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