Uniocular Anterior Chamber Inoculation of a Tumor Necrosis Factor Alpha-Expressing Recombinant of Herpes Simplex Virus Type 1 Results in More Rapid Destruction and Increased Viral Replication in the Retina of the Uninoculated Eye
Abstract:Tumor necrosis factor alpha (TNF-␣) has been shown to have a protective role in the eyes and brains of herpes simplex virus type 1 (HSV-1)-infected mice. To determine whether overexpression of TNF-␣ affected the course of virus infection following uniocular anterior chamber inoculation, a recombinant of HSV-1 that produces TNF-␣ constitutively (KOSTNF) was constructed. BALB/c mice were injected with the TNF-␣ recombinant, a recombinant containing the pCI plasmid, a recombinant rescue virus, or the parental vir… Show more
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