Unintentional ingestion of <i>Cordyceps</i> fungus-infected cicada nymphs causing ibotenic acid poisoning in Southern Vietnam

Doan, Uyen Vy; Rojas, Bomar Mendez; Kirby, Ralph

doi:10.1080/15563650.2017.1319066

Cited by 11 publications

(23 citation statements)

References 1 publication

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“…As Tricholoma and Amanita are related (taxonomic order Agaricales ), the biosynthesis of 6 should be similar to that of ibotenic acid, omitting the desaturation step. Further ibotenic acid‐ and tricholomic acid‐producing fungi have been proposed, ranging diverse taxa from Amantia species to Ustilago and Ophiocordyceps . The BGC reported here offers the opportunity to reassess the proposed producers on the genetic level, and thus verify or refute the hypothesis for further producers.…”

Section: Figurementioning

confidence: 76%

Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation

Obermaier

Müller

2020

Angew Chem Int Ed

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The fly agaric, Amanita muscaria, is widely known for its content of the psychoactive metabolites ibotenic acid and muscimol. However, their biosynthetic pathway and the respective enzymes are entirely unknown. 50 years ago, the biosynthesis was hypothesized to start with 3‐hydroxyglutamate. Here, we build on this hypothesis by the identification and recombinant production of a glutamate hydroxylase from A. muscaria. The hydroxylase gene is surrounded by six further biosynthetic genes, which we link to the production of ibotenic acid and muscimol using recent genomic and transcriptomic data. Our results pinpoint the genetic basis for ibotenic acid formation and thus provide new insights into a decades‐old question concerning a centuries‐old drug.

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Section: Figurementioning

confidence: 76%

Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation

Obermaier

Müller

2020

Angew Chem Int Ed

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“…A number of Rhizopus species, including Rhizopus arrhizus (OTU4 and OTU462) and Rhizopus microsporus (OTU21 and OTU16) are opportunistic agents of human zygomycosis (fungal infection) and can be pathogenic. , Some Aspergillus species detected in the P1 stage, including Aspergillus flavus (OTU9) and Aspergillus fumigatus (OTU34), account for the majority of invasive mold infections. , Aspergillus intermedius (OTU2850 and OTU15), Aspergillus piperis (OTU4559), and other unidentified species of Aspergillus , whose functions are unknown, could be beneficial or potentially harmful to humans. Moreover, cicada flowers infected by Ophiocordyceps heteropoda have been found to cause ibotenic acid poisoning …”

Section: Resultsmentioning

confidence: 99%

“…Moreover, cicada flowers infected by Ophiocordyceps heteropoda have been found to cause ibotenic acid poisoning. 36 According to the results of high-throughput sequencing, the fungus Isaria cicadae dominated, and this was not affected by the region, compartment, or growth stage. The results indicated that the genetics of the species Isaria cicadae was relatively stable, and the formation of the fruiting bodies of cicada flowers was mainly caused by the fungus Isaria cicadae.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae

Chunyu

Lü

Luo

et al. 2019

J. Agric. Food Chem.

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Cicada flowers, which are edible and medicinal mushrooms, are the fruiting bodies of Isaria cicadae, a fungus that is parasitic on the larvae of cicada pupae. We hypothesize that host factors might possess stimulatory activity on metabolite synthesis in Isaria cicadae. Here, we first compared the microbial community structures of different wild cicada flowers across geographical regions, compartments, and growth stages via high-throughput sequencing. Isaria cicadae TZC-3, an isolate of the most abundant operational taxonomic unit (OTU6782) in all the fungal communities, was isolated from wild cicada flowers. Furthermore, the effects of cicada pupae on metabolite synthesis in Isaria cicadae TZC-3 were studied in submerged culture. The contents of intercellular polysaccharides, adenosine, N6-(2-hydroxyethyl)-adenosine, free amino acids, and hydrolyzed monosaccharides in the mycelia cultured with cicada pupa powder (4%) were significantly increased as compared with the contents in the control group. This indicates that a cicada pupa can act as an elicitor for metabolite synthesis in Isaria cicadae.

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“…Another patient ingested 15-16 cicada flowers; although he exhibited severe symptoms, he survived after 3 weeks of treatment. These observations suggest that there are individual differences in the doses of cicada flower poisoning (Doan et al, 2017). It is therefore crucial to establish more systematic, complete, and feasible pharmacological and toxicological research methods.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products

Wang

Dai³

et al. 2022

Front. Pharmacol.

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At present, there is no effective drug for the treatment of renal fibrosis; in particular, a safe and effective treatment for renal fibrosis should be established. Cordyceps has several medical effects, including immunoregulatory, antitumor, anti-inflammatory, and antioxidant effects, and may prevent kidney, liver, and heart diseases. Cordyceps has also been reported to be effective in the treatment of renal fibrosis. In this paper, we review the potential mechanisms of Cordyceps against renal fibrosis, focusing on the effects of Cordyceps on inflammation, oxidative stress, apoptosis, regulation of autophagy, reduction of extracellular matrix deposition, and fibroblast activation. We also discuss relevant published clinical trials and meta-analyses. Available clinical studies support the possibility that Cordyceps and related products provide benefits to patients with chronic kidney diseases as adjuvants to conventional drugs. However, the existing clinical studies are limited by low quality and significant heterogeneity. The use of Cordyceps and related products may be a potential strategy for the treatment of renal fibrosis. Randomized controlled trial studies with good methodological quality, favorable experimental design, and large sample size are needed to evaluate the efficacy and safety of Cordyceps.

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Unintentional ingestion of Cordyceps fungus-infected cicada nymphs causing ibotenic acid poisoning in Southern Vietnam

Abstract: Cicada infected with Ophiocordyceps heteropoda in Vietnam contain ibotenic acid and are associated with a clinical syndrome consistent with its effects.

Cited by 11 publications

References 1 publication

Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation

Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation

Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae

Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products

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