Unintentional Ingestion of Bupropion in Children

Spiller, Henry A.; Beuhler, Michael C.; Gray, Ted; Baker, S. David

doi:10.1016/j.jemermed.2007.11.081

Cited by 13 publications

(7 citation statements)

References 11 publications

(18 reference statements)

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“…Further justification for this choice is that this is an easily remembered amount (less recall error by a specialist), it is less likely to result in mathematical error, only one in 2,465 cases had a seizure at this reported dose, and the clinical effects reported in this dose range were mostly mild. A recent study of 407 children after unintentional bupropion ingestion also suggested that a dose of 10 mg/kg or less could be safely managed at home [8]. Although there was some overlap in the two studied patient populations, this is similar to and supportive of our findings.…”

Section: Discussionsupporting

confidence: 90%

The Outcome of Unintentional Pediatric Bupropion Ingestions: A NPDS Database Review

2010

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Section: Discussionsupporting

confidence: 90%

The Outcome of Unintentional Pediatric Bupropion Ingestions: A NPDS Database Review

2010

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“…During the clinical studies, the all seizures incidents accompanied with bupropion treatment make up about 0.1%. Seizures in intoxication are common in adults but rare in children [11][12][13]. This is generally associated with children who does not take more than 1 -2 tablets [13].…”

Section: Discussionmentioning

confidence: 99%

Misdiagnosis of Bupropion Intoxication

et al. 2015

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Bupropion inhibits catecholamine's neuronal reuptake selectively but has a minimal effect on indolamine reuptake. It can be used in the treatment of major depressive disorder. A 3.5-year-old 15 kg girl had vomiting and disorders in her speech. After a time, she did not take breath and stared at one point and had a seizure. She was diagnosed with epilepsy and diazepam and then phenytoin was given intravenously. Midazolam infusion was performed. Although phenytoin loading and midazolam infusion, she had seizures intermittently. Her anamnesis in terms of drug story was rechecked but her family did not give any important data. Due to atypical process in clinical picture, multi-drug survey, stomach irrigation and activated charcoal were performed. The parent found bupropion which patient's mother had used. During 14 days follow-up, she was intubated and mechanical ventilation was performed. She had resuscitation for three times due to cardiopulmonary arrest. Fortunately, after successful conservative treatment, she was discharged without any neurological sequel. Neurologic effects are tremor, pain, hallucinations, coma and seizures. Cardiovascular effects are tachycardia and widening in QRS and lengthened QT interval. Gastrointestinal effects are nausea and vomiting. Deaths were reported rarely. In our case, the patient had most of the findings stated above. So that wide QRS tachycardia firstly, then bradycardia and asystole finally had developed. When child is admitted to emergency service with seizures, their parents must be asked about intoxication.

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“…7,16 This can be explained by the fact that usual accidental ingestions in children are of low doses of bupropion. In a retrospective study by Spiller et al, 12 reviewing bupropion ingestions in 407 children younger than 6 years, only 18% were symptomatic.…”

Section: Figurementioning

confidence: 99%

“…3 Status epilepticus and cardiogenic shock after massive bupropion ingestion has been reported in adults. 4 Seizures have been reported after bupropion overdose in an infant and children, [5][6][7] but no cases of status epilepticus have been reported in children. Refractory hypotension and transient cardiac dysfunction in an infant from a massive bupropion overdose have been described.…”

Section: Introductionmentioning

confidence: 99%