Unintentional buprenorphine and methadone poisoning in children: a matched observational study

Farnaghi, Fariba; Gholami, Narges; Hassanian‐Moghaddam, Hossein; McDonald, Rebecca; Zamanzadeh, Reza; Zamani, Nasim

doi:10.1080/15563650.2020.1869755

Cited by 6 publications

(8 citation statements)

References 16 publications

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“…Opioid substances that induce poisoning in-clude opium, heroin, cocaine, methadone, and codeine. Children, especially those under 6-year-old and elderly are subjected to unintentional poisoning with opiates more often than other age groups [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Methadone (Dolophine®) is a synthetic opioid substance with purely agonistic property, long half-life and high analgesic potential. It is an addictive substance; however, if it is consumed under clinical control and supervision, it reduces the need for consuming opioids un-der unsupervised conditions, such as home or streets [3,4]. Poisoning with opioids, such as methadone, is very serious and life-threatening in children [3].…”

Section: Introductionmentioning

confidence: 99%

“…It is an addictive substance; however, if it is consumed under clinical control and supervision, it reduces the need for consuming opioids un-der unsupervised conditions, such as home or streets [3,4]. Poisoning with opioids, such as methadone, is very serious and life-threatening in children [3]. The pattern of substance abuse is changing in today's society.…”

Section: Introductionmentioning

confidence: 99%

“…Pediatric poisoning with methadone is increasing in recent years. The unsafe storage of methadone syrups in bottles used for commercial beverages or water, or other drugs with similar appearances to water are the main reasons for the rise in pediatric poisoning with methadone [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Methadone Maintenance Treatment (MMT) program has been initiated in Iran since 2003 and has gradually grown such that there are more than 1500 centers offering this service in the country [3]. The unsafe storage of this substance at homes has given rise to children accidental access and toxicity in recent years [5].…”

Section: Introductionmentioning

confidence: 99%

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Changes in Opioid Poisoning Pattern in Children: A Retrospective Study in Rasht, Iran

Tabrizi

Sarabi

Taramsari

et al. 2021

IJT

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Background: Poisoning comprises about 7% of accidents in children under 5-year-old and 2% of all pediatric deaths in developing countries. To warn against and prevent future potential poisoning with opioid substances, this comparative study was conducted on pediatric cases referred to the 17th Shahrivar Hospital in Rasht, Iran, in 2006 and 2018. Methods: In this retrospective, cross-sectional study, all hospitalized pediatric cases diagnosed with opioid poisoning in 2006 and 2018 were investigated systematically. The demographic data, such as age, gender, city or village of residence, the poisoning substances involved, and the clinical outcomes were extracted from the medical records and entered on an appropriately-designed form. The data analysis was performed, using SPSS software, version 21. Results: Fifty pediatric cases were examined with a mean age of 44.38±3.8 months old. Among these cases, 14 children had been poisoned, 13 of whom with opium and one with morphine in 2006; while in 2018, 36 children had been poisoned with methadone and only one with opium. Conclusion: Comparing years 2006 with 2018, a considerable increase in pediatric opioid poisoning cases was observed with a tendency toward methadone being the substance involved. The occurrences might be due to unsafe access of unaware children to this drug, especially after the initiation of methadone maintenance treatment for opiate addicts, who were mainly the parents or relatives living in the same household.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%