Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections

Dauby, Nicolás; Goetghebuer, Tessa; Kollmann, Tobias R.; Levy, Jack S.; Marchant, Arnaud

doi:10.1016/s1473-3099(11)70341-3

Cited by 157 publications

(152 citation statements)

References 140 publications

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“…During pregnancy, maternal infections can affect the development of foetal immune systems independently of the vertical transmission of pathogens (Dauby, et al, 2012).…”

Section: Healthmentioning

confidence: 99%

“…It has also been shown that infants exposed to placental malaria in utero are more susceptible to acquiring HIV through mother-to-child transmission (Steiner, et al, 2010). Infants born to mothers with placental malaria also had an increased risk of acquiring malaria postnatally (Dauby, et al, 2012), which can cause neurological and cognitive impairments (Walker, et al, 2007b).…”

Section: Infectionsmentioning

confidence: 99%

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Developmental delay in HIV-exposed infants in Harare, Zimbabwe

Hutchings¹,

Potterton

2013

Vulnerable Children and Youth Studies

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The aim of this cross-sectional study was to determine the difference in development (cognition; receptive and expressive language; and fine and gross motor) of Human Immunodeficiency Virus (HIV) -exposed infected (HEI) infants with the development of HIV-exposed but uninfected (HEU) infants using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Sixty infants were enrolled in the study; 32 (53.33%) HEU infants and 28 (46.67%) HEI infants. The two groups were well-matched for infant demographics, anthropometry at birth, maternal demographics, as well as socioeconomic status. Statistically significant differences were found in anthropometry and development between the HEI and HEU group. The HEI infants had malnutrition, were stunted and had smaller head circumferences than HEU infants. The BSID-III showed that the mean developmental delay for the HEI group was approximately two months below their mean chronological age for all scales (cognitive; receptive and expressive communication; and, fine and gross motor age).The HEI group showed that 64.29% had cognitive delay, 60.71% had language delay and 53.57% had motor delay, all of which was significantly different from the development of the HEU group for all domains (p<0.001). In addition to using the BSID-III, the majority of mothers were able to correctly indicate whether their child was developing at the same, or at a slower rate of development than children of the same age. This study demonstrates that infants who are HIV-exposed and infected are at risk of developmental delay.

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“…During pregnancy, maternal infections can affect the development of foetal immune systems independently of the vertical transmission of pathogens (Dauby, et al, 2012).…”

Section: Healthmentioning

confidence: 99%

Section: Infectionsmentioning

confidence: 99%

Developmental delay in HIV-exposed infants in Harare, Zimbabwe

Hutchings¹,

Potterton

2013

Vulnerable Children and Youth Studies

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“…23,24 Because pregnancy-associated malaria is an important cause of maternal and fetal morbidity and mortality, 25 in a malaria high-risk area such as Cotonou, acute CHIKV infection of a malaria-infected woman close to delivery could worsen pregnancy outcome. We observed that, among 56 women who had P. falciparum infection during pregnancy, 17 (30.3%) women were positive for CHIKV IgG, but none exhibited anti-CHIKV IgM.…”

mentioning

confidence: 99%

High Seroprevalence of Chikungunya Virus Antibodies Among Pregnant Women Living in an Urban Area in Benin, West Africa

Bacci¹,

Marchi²,

Fiévet³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The aim of this study was to investigate the seroprevalence of antichikungunya virus (anti-CHIKV) antibodies in pregnant women living in an urban area of Benin (West Africa). Results were obtained by screening sera collected in 2006 and 2007 with enzyme-linked immunosorbent assay (ELISA) for anti-CHIKV immunoglobulin G (IgG) and IgM. Positive results were confirmed by indirect immunofluorescence test and microneutralization assay. We found that a large proportion (36.1%) of pregnant women living in Cotonou had specific IgG against CHIKV, indicating a high seroprevalence of the infection in urban southern Benin, whereas no active cases of CHIKV infection were detected.Arboviruses that are transmitted by Aedes mosquitoes, such as dengue virus and chikungunya virus (CHIKV) infections, are a global threat because of their rapid and abrupt spread worldwide and the infection-related disease burden.

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“…Les données humaines sont plus difficiles à interpréter et encore discordantes. L'infection maternelle par le VIH pourrait -au moins en théorie -influencer la mitochondrie du foetus et du nouveauné [17]. Une récente analyse biochimique et moléculaire reproduit toutefois assez bien les données expérimentales animales.…”

Section: Risque De Prématuritéunclassified

Tolérance pour l’enfant des antirétroviraux durant la grossesse

Blanche

Warszawski

2013

Med Sci (Paris)

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Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections

Cited by 157 publications

References 140 publications

Developmental delay in HIV-exposed infants in Harare, Zimbabwe

Developmental delay in HIV-exposed infants in Harare, Zimbabwe

High Seroprevalence of Chikungunya Virus Antibodies Among Pregnant Women Living in an Urban Area in Benin, West Africa

Tolérance pour l’enfant des antirétroviraux durant la grossesse

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