Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States

Hosier, Hillary; Sheth, Sangini S.; Oliveira, Carlos Rocha; Perley, Lauren; Vash‐Margita, Alla

doi:10.1016/j.ajog.2021.07.005

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Current consensus does not recommend the initiation of cervical cancer screening before the age of 21 years in immunocompetent females due to the very low rate of cervical cancer among women aged 20 to 24 years (0.8 per 100,000). [12] In Egypt, there is a social tendency for early marriage, and the results of this study revealed that epithelial abnormalities are associated with earlier sexual activity. This might have implications for practice.…”

Section: Key Resultsmentioning

confidence: 65%

Utilization of cervical cancer screening by cytology and the burden of epithelial abnormalities: A tertiary-center 42-year study

Ezzelarab,

ElHusseiny,

Nasreldin

et al. 2024

Preprint

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Background: Cytological screening remains a high-impact practice, particularly in low-resource settings, for preventing cervical cancer. The examination of screening practices over time and the prevalence of epithelial abnormalities have not been investigated in longitudinal studies in one of the largest countries in the Middle East and Africa. Methods: Routine healthcare data were collected from March 1981 to December 2022 at the Early Cancer Detection Unit in a tertiary referral university hospital in the Greater Cairo Region, Egypt. Cervical smears were obtained using a standardized technique and sent to the cytopathology laboratory for conventional cytology examination by expert pathologists. The data were analyzed to determine the temporal trend of the number of women screened each year and the prevalence of epithelial abnormalities. Results: Data included the results of satisfactory smears from 95120 women. The mean age (SD) of the women at the time of screening was 38.5 (10.5). None of the included women received an HPV vaccine. Abnormal epithelial cells were reported in 5174 women (5.44%). Of these epithelial abnormalities, the majority were low-grade squamous intraepithelial lesions in 4144 women (4.36%). Other abnormalities included atypical squamous cells in 378 women (0.40%), high-grade squamous intraepithelial lesions in 226 women (0.24%), atypical glandular cells not otherwise specified in 184 women (0.19%), adenocarcinoma in 165 women (0.17%), squamous cell carcinoma in 70 women (0.07%), and atypical glandular cells favoring neoplasms in 7 women (0.01%). Women who were at an early age at first intercourse, those who opted for routine cervical cytology screening, and those who were older at screening were more likely to have epithelial abnormalities. The yearly number of screened women was positively associated with the detection of low-grade squamous intraepithelial lesions (correlation coefficient [95% CI] = 0.84 [0.72, 0.91]) and negatively associated with the detection of squamous cell carcinoma (correlation coefficient [95% CI] = -0.55 [-0.73, -0.29]). Conclusions: The small number of annually screened Egyptian women and the temporal trend in epithelial abnormalities critically demonstrate the need for establishing and scaling up a structured population-based program to achieve the goal of eliminating cervical cancer.

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Section: Key Resultsmentioning

confidence: 65%

Utilization of cervical cancer screening by cytology and the burden of epithelial abnormalities: A tertiary-center 42-year study

Ezzelarab,

ElHusseiny,

Nasreldin

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Current consensus does not recommend the initiation of cervical cancer screening before the age of 21 years in immunocompetent females due to the very low rate of cervical cancer among women aged 20 to 24 years (0.8 per 100,000) [ 12 ]. In Egypt, there is a social tendency for early marriage, and the results of this study revealed that epithelial abnormalities are associated with earlier sexual activity.…”

Section: Discussionmentioning

confidence: 99%

Cervical cancer screening by cytology and the burden of epithelial abnormalities in low resource settings: a tertiary-center 42-year study

Ezzelarab,

El-Husseiny,

Nasreldin

et al. 2024

BMC Women's Health

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Background Cytological screening remains a high-impact practice, particularly in low-resource settings, for preventing cervical cancer. The examination of screening practices over time and the prevalence of epithelial abnormalities have not been investigated in longitudinal studies in one of the largest countries in the Middle East and Africa. Methods Routine healthcare data, between March 1981 and December 2022, were extracted from the database of the Early Cancer Detection Unit in a tertiary referral university hospital in the Greater Cairo Region, Egypt. Cervical smears were obtained using a standardized technique and sent to the cytopathology laboratory for conventional cytology examination by expert pathologists. The anonymous data were analyzed to determine the temporal trend of the number of women screened each year and the prevalence of epithelial abnormalities. Results Data included the results of satisfactory smears from 95120 women. The mean age (SD) of the women at the time of screening was 38.5 (10.5). None of the included women received an HPV vaccine. Abnormal epithelial cells were reported in 5174 women (5.44%). Of these epithelial abnormalities, the majority were low-grade squamous intraepithelial lesions in 4144 women (4.36%). Other abnormalities included atypical squamous cells in 378 women (0.40%), high-grade squamous intraepithelial lesions in 226 women (0.24%), atypical glandular cells not otherwise specified in 184 women (0.19%), adenocarcinoma in 165 women (0.17%), squamous cell carcinoma in 70 women (0.07%), and atypical glandular cells favoring neoplasms in 7 women (0.01%). Women who were at an early age at first intercourse, those who opted for routine cervical cytology screening, and those who were older at screening were more likely to have epithelial abnormalities. The yearly number of screened women was positively associated with the detection of low-grade squamous intraepithelial lesions (correlation coefficient [95% CI] = 0.84 [0.72, 0.91]) and negatively associated with the detection of squamous cell carcinoma (correlation coefficient [95% CI] = -0.55 [-0.73, -0.29]). Conclusions The small number of annually screened Egyptian women and the temporal trend in epithelial abnormalities critically demonstrate the need for establishing and scaling up a structured population-based program to achieve the goal of eliminating cervical cancer.

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“…In most cases, cervical cancer tends to be malignant, which contributes to its high incidence and mortality rate ( 48 , 49 ). The main treatment options include surgery and radiotherapy, but their efficacy is minimal, with a mortality rate of more than 85% in developing countries ( 93 , 94 ). The incidence of most cancers increases with age; however, in the unscreened population, cervical cancer rates plateau at 40-45 years of age.…”

Section: Circ_0007534 Dysregulation In Cancers and Its Mechanismsmentioning

confidence: 99%

Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions

Liu

Dong²,

Chen³

et al. 2022

Front. Oncol.

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Circular RNA (circRNAs), an important member of the non-coding RNA (ncRNA) family, are widely expressed in a variety of biological cells. Owing to their stable structures, sequence conservations, and cell- or tissue-specific expressions, these RNA have become a popular subject of scientific research. With the development of sequencing methods, it has been revealed that circRNAs exert their biological function by sponging microRNAs (miRNAs), regulating transcription, or binding to proteins. Humans have historically been significantly impacted by various types of cancer. Studies have shown that circRNAs are abnormally expressed in various cancers and are involved in the occurrence and development of malignant tumors, such as tumor cell proliferation, migration, and invasion. As one of its star molecules, circ_0007534 is upregulated in colorectal, cervical, and pancreatic cancers; is closely related to the occurrence, development, and prognosis of tumors; and is expected to become a novel tumor marker and therapeutic target. This article briefly reviews the expression and mechanism of circ_0007534 in malignant tumors based on the domestic and foreign literature.

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Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States

Cited by 5 publications

References 26 publications

Utilization of cervical cancer screening by cytology and the burden of epithelial abnormalities: A tertiary-center 42-year study

Utilization of cervical cancer screening by cytology and the burden of epithelial abnormalities: A tertiary-center 42-year study

Cervical cancer screening by cytology and the burden of epithelial abnormalities in low resource settings: a tertiary-center 42-year study

Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions

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