Unilateral tongue angioedema caused by angiotensin-converting enzyme inhibitor

Ee, Young; Sow, AJ; Goh, Bee See

doi:10.1017/s002221511000143x

Cited by 9 publications

(1 citation statement)

References 10 publications

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“…This is a very rare angioedema presentation with few cases reported in the literature. [7][8][9][10][11][12][13] The cause of this specific involvement remains uncertain, but one theory states that unilateral edema might be the progression over time to bilateral edema. 14 Although rare, this presentation should be considered in this diagnosis due to the risk of progression to airway obstruction.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Unilateral Tongue Edema with Angiotensin Converting Enzyme Inhibitors

Braga¹,

Cravo²,

Neves³

et al. 2022

Acta Med Port

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Angiotensin converting enzyme inhibitors (ACEi) are widely used for the treatment of multiple conditions such as hypertension, heart failure and chronic kidney disease. Angioedema is a rare but potentially fatal complication of ACEi use and unilateral tongue edema is a very rare presentation. We report a case of a 55-year-old man, with a history of hypertension, on enalapril for three years, who presented to the hospital with unilateral tongue swelling, without airway compromise. Other causes were excluded and the diagnosis of angioedema due to enalapril was established. The patient was discharged with discontinuation of ACEi with total resolution of symptoms and without relapse after several months. Although very rare, unilateral tongue swelling should be considered in the presentation of angioedema associated with ACEi. Tight surveillance is important to prevent fatal complications such as airway obstruction. ACEi discontinuation is crucial to avoid clinical relapse.

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