Unilateral systematized linear porokeratosis: A report of a rare case

Kudligi, Chandramohan; Bhagwat, Pradeep Vittal; Giriyan, Sujata S.; Eshwarrao, Mohan Shendre

doi:10.4103/0019-5154.84725

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Raised, irregularly shaped pigmented or nonpigmented macules with a blaschkoid distribution and surrounded with cornoid lamellae usually develop on the extremities (Figure 10) [114,379], whereas facial, genital and plantar distribution is rare [52,378,380]. The lesions are usually unilateral, yet bilateral or generalised LPs have also been also reported [52,114,377,[381][382][383]. The plaques are anhidrotic and alopecic [384] and rarely may start as erosions [376].…”

Section: Linear Porokeratosis (Lp) 61 Clinical Presentationmentioning

confidence: 99%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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Section: Linear Porokeratosis (Lp) 61 Clinical Presentationmentioning

confidence: 99%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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“…The lesions usually follow a dermatomal distribution. [63][64][65][66][67][68] Loss of heterozygosity has been proposed as the pathomechanism and this could be responsible for the higher chances of malignant transformation. 69 No inheritance is, however, reported.…”

Section: Linear Porokeratosismentioning

confidence: 99%

Porokeratosis: An enigma beginning to unravel

Das¹,

Vasudevan

Talwar³

2021

IJDVL

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Porokeratosis is a keratinization disorder with unclear etiopathogenesis, varied clinical presentation and characteristic histopathology, and is usually unresponsive to current therapeutic options. Until now, it was considered to be a clonal disorder with immunity, ultra violet radiation and other factors playing important roles in etiopathogenesis. It is now known that abnormalities in the mevalonate pathway are responsible for this clonal keratinization abnormality. New variants of porokeratosis like eruptive bullous, pruriginous, lichen planus like, follicular variants and porokeratoma have been described. While the cornoid lamella is the classical histopathologic feature, dermoscopy and reflectance confocal microscopy make the diagnosis clearer. Development of malignancy in a few variants is a concern. Linear, disseminated superficial actinic and giant lesions are most prone to developing malignancies. Bowen’s disease, squamous cell carcinoma, basal cell carcinoma and even melanoma have been reported in cases of long-standing porokeratosis. Newer modalities of therapy such as photodynamic therapy, ingenol mebutate and HMGCoA inhibitors may play a role in the future.

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Unilateral systematized linear porokeratosis: A report of a rare case

Cited by 2 publications

References 4 publications

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Porokeratosis: An enigma beginning to unravel

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