Unilateral Renal Vein Thrombosis and Adrenal Hemorrhage in A Newborn with Homozygous Factor V Leiden and Heterozygous Of MTHFR-677T, MTHFR-1298C Gene Mutations

Abstract

Renal vein thrombosis (RVT) occurs as an acute and life-threatening event in neonates.

Thrombosis of Bilateral Renal Veins, Inferior Vena Cava, and Superior Sagittal Sinus with Adrenal Hemorrhage in a Neonate

“…2 The thrombus may extend into IVC in 40-50% of cases and 15% may have adrenal hemorrhage. [3][4][5][6] Only 10-15% had classical triad palpable flank mass, hematuria, and renal failure. 1 The usual time of presentation is within the first 3 days of life, as in index case.…”

“…Guruprasad Peruri 1 , Suresh K Angurana 2 , Renu Suthar 3 , Venkataseshan 4 , Vichithra Mohandoss 5 , Anmol Bhatia 6…”

“…1,2 Risk factors for thrombosis in neonates include vascular catheters, birth asphyxia, dehydration, sepsis, acidosis, polycythemia, gestational diabetes mellitus (GDM), cyanotic heart diseases, inherited thrombophilia (deficiency of protein C, protein S, and antithrombin III), and acquired thrombophilia [placental transfer of antiphospholipid antibodies (APLA) and maternal autoimmune disorders. 1,3,4 Renal vein thrombosis (RVT) is the commonest noncatheter related thrombosis in neonates 2,3 and can lead to longterm renal impairment. Cerebral sinovenous thrombosis (CSVT) though rare in neonates can lead to morbidities like seizures, cerebral palsy, and cognitive impairment.…”

Acute Pyelonephritis: The Clot Unfolds, Evidence than Supports Complex Nature of the Renal Vein Thrombosis; Therapeutical Implications

“…Also we must investigate the correlation of thrombofilia with development of bilateral RVT, as well as the interaction with environmental factors such as infections. In some cases the mutations are determinant of clinical phenotype; the multigenic thrombophilia is associated with massive IVCT, NS and chronic bilateral pulmonary artery thromboembolism [9,10]. There are cases of unilateral RVT that are associated with SERPINE1 4G, FVL, heterozygous of MTHFR-677T, MTHFR-1298C gene mutations.…”