Unilateral recurrent central serous chorioretinopathy (CSCR) following COVID-19 vaccination- A multimodal imaging study

Sanjay, Srinivasan; Acharya, Isha; Kawali, Ankush; Shetty, Rohit; Mahendradas, Padmamalini

doi:10.1016/j.ajoc.2022.101644

Cited by 5 publications

(5 citation statements)

References 25 publications

(39 reference statements)

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“…Central serous chorioretinopathy (CSCR) is a common, idiopathic cause of sub-retinal fluid in mostly young patients. Serous detachments were described within 1 week after vaccination with either a vector or an mRNA COVID-19 vaccine, both in patients already diagnosed with CSCR and patients who were never had any complaints [7, 8]. Vogt-Koyanagi-Harada disease has been reported 14–35 days after mRNA and inactivated virus COVID-19 vaccines [9‒12].…”

Section: Conclusion and Discussionmentioning

confidence: 99%

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Bilateral Serous Detachments with Roth Spots after COVID-19 Vaccination: A Case Report

Jalink

Thesingh

2023

Case Rep Ophthalmol

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With the rise of novel types of vaccines during the pandemic, new side effects are encountered. The aim of this paper is to describe an atypical case of bilateral serous detachments with Roth spots after COVID-19 vaccination using an mRNA vaccine. A healthy, 38-year-old male presented with a central scotoma and metamorphopsia in his left eye, 4 days after his second COVID-19 booster shot. Bilateral serous detachments were seen, with one area showing Roth spots. Patient’s symptoms resolved spontaneously without any treatment. Although serous detachment after COVID-19 vaccination has been described in the context of other diseases, such as Vogt-Koyanagi-Harada disease, central serous chorioretinopathy, and posterior scleritis, this is the first report of serous detachments with Roth spots as an isolated entity.

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Section: Conclusion and Discussionmentioning

confidence: 99%

“…vaccination with either a vector or an mRNA COVID-19 vaccine, both in patients already diagnosed with CSCR and patients who were never had any complaints [7,8]. Vogt-Koyanagi-Harada disease has been reported 14-35 days after mRNA and inactivated virus COVID-19 vaccines [9][10][11][12].…”

Section: Case Reports In Ophthalmologymentioning

confidence: 99%

Bilateral Serous Detachments with Roth Spots after COVID-19 Vaccination: A Case Report

Jalink

Thesingh

2023

Case Rep Ophthalmol

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“…In this table, we summarized the observations of MCI and its advantages found in published papers. The list is not exhaustive; however, it highlights the salient features of different retinal and choroidal disorders [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Multi-color imaging in a unilateral central retinal artery occlusion following dengue fever: A case report and literature review

Sanjay¹,

Kawali²,

Gopalakrishnan³

et al. 2022

Med Hypothesis Discov Innov Optom

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Background: Dengue fever is associated with various sight-threatening ocular manifestations, some of which can occur several months after fever. These include subconjunctival hemorrhage, vitreous hemorrhage, retinal hemorrhage, cotton wool spots, central and branch retinal artery occlusion, central scotoma, papilledema, optic neuropathy, retinal vasculitis, retinitis, retinal pigment epithelium mottling, foveolitis, choroidal effusion, exudative retinal detachment, anterior uveitis, endogenous endophthalmitis, and panophthalmitis. Herein, we report a patient with unilateral central retinal artery occlusion (CRAO) and raised dengue immunoglobulin G (IgG) titers who underwent serial multimodal imaging with fundus photography, spectral domain optical coherence tomography (SD-OCT), optical coherence tomography angiography (OCTA), and multi-color imaging (MCI). Furthermore, we reviewed recent publications highlighting different eye diseases and the role of MCI in their diagnosis and serial monitoring. Case presentation: A 53-year-old Asian Indian woman complained of blurring of vision in the right eye (OD) two months after a bout of fever. Her best-corrected distance visual acuity was finger counting close to the face in the OD and 20/40 in the left eye. CRAO of the OD was diagnosed. Systemic investigations were normal except for elevated dengue IgG levels. Optical coherence tomography and fluorescein angiography confirmed this diagnosis. MCI and SD-OCT using Spectralis™ performed before and after treatment with oral steroids demonstrated improvement. MCI served as a noninvasive ancillary tool for monitoring the CRAO. In addition to the case report, we summarize articles pertaining to MCI published during the years 2018–2022. The list is not exhaustive but highlights salient features of different retinal and choroidal disorders evaluated using MCI. Our summary highlights the role of MCI in the diagnosis and serial monitoring of eye diseases. Conclusions: A diagnosis of post-dengue fever retinal artery occlusion should be made after ruling out other causes of retinal artery vascular occlusion. We demonstrated retinal changes using serial imaging. MCI can be a useful tool, along with SD-OCT, to monitor clinical improvement. Optometrists can follow up patients with retinal vascular occlusions using noninvasive methods.

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“…by various other authors. [12][13][14][15][16][17] Most cases were observed without therapy, and 2 had been prescribed eplerenone. 13,17 Overall, the prognosis was good.…”

Section: Rhegmatogenous Retinal Detachment After Covid-19 Vaccinationmentioning

confidence: 99%

Retinal Detachment Following Vaccination against COVID-19: A Narrative Literature Review

Markov¹,

Zdravkov²,

Oscar³

2023

sjo

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Retinal detachment (RD) refers to the anatomical separation of the neurosensory retina from the Retinal pigment epithelium, which, if untreated, ultimately leads to a loss of visual function and blindness. Three main types are recognised based on the pathogenesis: rhegmatogenous, associated with retinal tears/holes; tractional, where there is pulling on the retina from preretinal and/or vitreal fibrotic changes; and exudative or serous, in which the subretinal fluid is due to transudation, exudation, or impaired outer blood-retina barrier. The infection with SARS-CoV-2 has not been directly associated with any type of RD, except in cases of secondary infections or autoimmune conditions. Serous retinal detachment has very rarely been observed following the application of various vaccines against COVID-19, but only in the setting of central serous chorioretinopathy and uveitis. The single case of purported rhegmatogenous detachment has a highly improbable connection with the vaccination. All in all, the described complications have been extremely uncommon, more frequently treatable or self-resolving, and should not discourage COVID-19 vaccination.

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Unilateral recurrent central serous chorioretinopathy (CSCR) following COVID-19 vaccination- A multimodal imaging study

Cited by 5 publications

References 25 publications

Bilateral Serous Detachments with Roth Spots after COVID-19 Vaccination: A Case Report

Bilateral Serous Detachments with Roth Spots after COVID-19 Vaccination: A Case Report

Multi-color imaging in a unilateral central retinal artery occlusion following dengue fever: A case report and literature review

Retinal Detachment Following Vaccination against COVID-19: A Narrative Literature Review

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