Unilateral prurigo nodularis: a rare presentation

Bhatia, Kailash; Kataria, Rajesh; Parekh, Niyati; Kothari, Jayesh; Kumar, Ravindra

doi:10.5455/2320-6012.ijrms20140824

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2022

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“…Asymmetrical PN, although rare, is a recognized entity usually associated with paralysis and strokes. In some rare cases, the underlying etiology may remain unknown [5]. Various treatments such as steroids, thalidomide, cryotherapy, and immunosuppressants have been proposed, with unsatisfactory results [6,7].…”

Section: Introductionmentioning

confidence: 99%

Post-Stroke Asymmetric Prurigo Nodularis Responding to Dupilumab Treatment: A Case Report

Sammarra

Bennardo

Provenzano³

et al. 2022

Brain Sciences

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Prurigo nodularis (PN) is a dermatological condition characterized by nodular hyperkeratotic lesions mainly on the legs and arms. Asymmetrical PN is a rare dermatological condition often associated with paralysis and stroke. In this paper, we present the case of a 77-year-old woman who developed post-ictal PN which responded to dupilumab, an anti-interleukin-4/13 drug approved for the management of AD, with an extreme reduction in itch sensation. Dupilumab and other therapies reducing Th2 inflammation may, in the future, become an alternative treatment for post-ictal pruritus/PN nonresponding to traditional therapies. Of course, larger studies will be necessary to confirm our case’s findings.

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Section: Introductionmentioning

confidence: 99%