Unilateral nevoid hyperkeratosis of the nipple and areola in a Saudi female

Abstract

An otherwise healthy, 21-year-old, single Saudi female presented to the outpatient dermatology clinic with a 3-year history of progressive skin thickening and darkening of the left nipple, associated with moderate ABSTRACT Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare, benign condition of unknown origin that is characterized by a hyperpigmented, hyperkeratotic verruca plaque over the nipple and/or areola. NHNA usually occurs bilaterally, but is sometimes present unilaterally. We present a case of a 21-year-old Saudi female who presented at dermatology outpatient clinic with a 3-year history of skin darkening and thickening of the left nipple, associated with moderate itching. The patient was diagnosed with unilateral NHNA on the basis of clinical presentation and skin-punch biopsy findings of epidermal orthokeratotic hyperkeratosis, mild papillomatosis, basal-layer hyperpigmentation and irregular filiform-pattern epidermal acanthosis. To the best of our knowledge, this case represents the first report of NHNA with unilateral presentation in a Saudi female.

Nevoid hyperkeratosis of the nipple and areola

“…Primary or idiopathic and secondary. If it is accompanied by other skin lesions such as epidermal nevus, seborrheic keratosis, acanthosis nigricans, or the lesions that develop after drug use are called secondary type [5]. In our patients, there was no other skin lesions or medicine usage and her lesions are idiopathic.…”