Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal firing of the midbrain raphe nuclei 5-HT neurons and a decrease of their response to 5-HT1A receptor stimulation in the rat

Wang, S.; Zhang, Q.J.; Liu, J.; Wu, Zihui; Wang, T.; Gui, Zhen; Chen, L.; Wang, Y.

doi:10.1016/j.neuroscience.2008.12.051

Cited by 83 publications

(48 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, some authors have reported an increase (Kaya et al 2008 ;Wang et al 2009a ;Zhang et al 2007a), while others have observed a decrease (Guiard et al 2008b) in the firing rate of DRN neurons in parkinsonian rats under basal conditions. These discrepancies, reminiscent of those found with LC neurons in parkinsonian rats, could also be attributed to methodological factors.…”

Section: Discussionmentioning

confidence: 97%

Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease

Miguélez

Grandoso

Ugedo

2010

Int. J. Neuropsychopharm.

View full text Add to dashboard Cite

In addition to noradrenergic and serotonergic systems, dopaminergic neurotransmission seems to play an important role in the aetiopathogenesis of, and recovery from, depression. Moreover, the incidence of depression is higher in patients affected by diseases where the dopaminergic system is highly impaired, such us Parkinson's disease. Here, we investigated the effects of dopamine degeneration on the activity and response to antidepressants of locus coeruleus (LC) noradrenergic and dorsal raphe nucleus (DRN) serotonergic neurons. To this end, single-unit extracellular recordings were performed in control and 6-hydroxydopamine (6-OHDA)-lesioned animals. In this latter group, LC neurons showed a lower basal firing rate as well as less sensitivity to the administration of the serotonin reuptake inhibitor, fluoxetine. The rest of electrophysiological parameters and the response to the administration of the a 2 -adrenoceptor agonist, clonidine and the noradrenaline reuptake inhibitor, reboxetine remained unaltered. In the DRN, dopamine depletion did not modify the basal electrophysiological characteristics and the response to clonidine or fluoxetine administration. In contrast, the administration of reboxetine more efficiently induced an inhibitory effect in the lesioned group. In additional analyses it was observed that while in control animals, LC and DRN basal firing rate was significantly correlated, this relationship was lost after the 6-OHDA lesion. In conclusion, dopaminergic degeneration alters LC neuron basal activity, the relationship/syntony between both nuclei, and their response to antidepressants. These findings shed fresh light on our understanding of the role of dopamine in depression and the mechanism action of antidepressants.

show abstract

Section: Discussionmentioning

confidence: 97%

Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease

Miguélez

Grandoso

Ugedo

2010

Int. J. Neuropsychopharm.

View full text Add to dashboard Cite

show abstract

“…The majority of publications describe effects of unilateral 6-OHDA injections into the medium forebrain bundle and their behavioural laterality effects on the motor system (Castellano et al 1987(Castellano et al , 1989Metz et al 2004;Baluchnejadmojarad and Roghani 2004;Iancu et al 2005;Avila et al 2010). Also, to characterise the ipsi-and contralateral nigro-striatal systems neurochemical parameters such as dopaminergic and GABA-ergic components (González-Hernández et al 2004), neurotrophic factors and NMDA-receptors (Bustos et al 2009) or serotoninergic parameters (Wang et al 2009) were employed.…”

Section: -Ohda Model and Lateralisationmentioning

confidence: 99%

The significance of neuronal lateralisation in Parkinson’s disease

Riederer

Sian-Hülsmann

2012

J Neural Transm

View full text Add to dashboard Cite

The destruction of the dopaminergic neurons in the substantia nigra (SN) and consequent depletion of striatal dopamine elicits the main movement deficits related to Parkinson's disease (PD). In the early stages of the illness, the motor symptoms are often exhibited asymmetrically. Thus, the onset of PD features starts on either the right or left side. The side of onset appears to determine the prognosis of the disorder and other features, such as right-side tremor dominance has a better prognosis in contrast to left-side dominant bradykinesia-rigidity. In addition, left-side onset of motor features is associated with cognitive decline. Therefore, an intricate relation appears to exist between the side of disease onset and progression/severity and other non-motor symptoms. Unilateral PD in turn corresponds to neuronal nigrostriatal degeneration in the contralateral hemisphere. Indeed positron emission tomography has demonstrated a positive correlation between symptom asymmetry and brain function (Hoorn et al. Parkinsonism Relat Disord 17:58-60, 2011), which corresponds to a unilateral pattern of degeneration. This phenomenon appears to be exclusive to PD. Additionally, the variation in motor symptom(s) dominance exhibited in the disorder conforms to the notion that PD is a spectrum disease with many sub-groups. Thus, clinical and post mortem studies on "lateralisation" may serve as a vital tool in understanding the mechanism(s) eliciting the characteristic destruction of the SN neurons. Additionally, it may be employed as a predictive indicator for the symptomology and prognosis of the illness thus allowing selective treatment strategies targeted at the pronounced hemispheric degeneration.

show abstract

“…Changes of 5-HT system activity after DA lesion have been reported, however, but the data are controversial. Some studies have shown an overall hyperactivity of the 5-HT system (Commins et al, 1989;Zhou et al, 1991) with an increased activity of DRN and MRN 5-HT neurons (Temel et al, 2007;Kaya et al, 2008;Wang et al, 2009), while other studies have reported a significant reduction in 5-HT function (Takeuchi et al, 1991) with a decreased activity of DRN 5-HT neurons (Guiard et al, 2008). It is interesting to note that modifications of basal 5-HT release in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys depend on the functional territories considered (Boulet et al, 2008).…”

Section: Stn-hfs Inhibits 5-ht Release: Role Of 5-ht Neuronal Activitymentioning

confidence: 99%

High-Frequency Stimulation of the Subthalamic Nucleus and l-3,4-Dihydroxyphenylalanine InhibitIn VivoSerotonin Release in the Prefrontal Cortex and Hippocampus in a Rat Model of Parkinson's Disease

Navailles¹,

Benazzouz²,

Bioulac³

et al. 2010

J. Neurosci.

View full text Add to dashboard Cite

show abstract

Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal firing of the midbrain raphe nuclei 5-HT neurons and a decrease of their response to 5-HT1A receptor stimulation in the rat

Cited by 83 publications

References 64 publications

Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease

Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease

The significance of neuronal lateralisation in Parkinson’s disease

High-Frequency Stimulation of the Subthalamic Nucleus and l-3,4-Dihydroxyphenylalanine InhibitIn VivoSerotonin Release in the Prefrontal Cortex and Hippocampus in a Rat Model of Parkinson's Disease

Contact Info

Product

Resources

About