Unilateral keratotic vascular lesion on the leg. Verrucous hemangioma

Ds, Wong; Sj, Hunt; Dw, Inserra; Abell, Edward

doi:10.1001/archderm.132.6.705

Cited by 12 publications

(8 citation statements)

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“…Our findings in VH are similar to the clinical and pathologic descriptions of Imperial and Helwig (9) and other investigators (17,19–22). Verrucous hemangioma presents in infancy, occurs primarily on the extremities, and is single or grouped.…”

Section: Discussionsupporting

confidence: 92%

“…The old names for hyperkeratotic vascular lesions confound our understanding of VH. For example, Imperial and Helwig (9) designated VH as a vascular malformation, but in the same paper they also described VH as a “structural variant of capillary or cavernous hemangioma.” Others have referred to VH as a vascular malformation and used the term “deep hemangioma” in the same article (19,21).…”

Section: Discussionmentioning

confidence: 99%

“…Verrucous hemangioma presents in infancy, occurs primarily on the extremities, and is single or grouped. Early on, the lesions are nonkeratotic, soft, and bluish‐red, but in time they become increasingly hyperkeratotic (9,17,19–22). Verrucous hemangiomas persist indefinitely and do not regress and are therefore similar in behavior to vascular malformations.…”

Section: Discussionmentioning

confidence: 99%

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Verrucous Hemangioma Revisited

Tennant¹,

Mulliken

Perez‐Atayde³

et al. 2006

Pediatric Dermatology

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We analyzed the clinical and histopathologic characteristics of verrucous hemangioma, compared these findings to hyperkeratotic mimickers such as capillary-lymphatic malformation or capillary-venous malformation and angiokeratoma circumscriptum, and reconsidered whether the term verrucous hemangioma is appropriate in the current nosology of vascular anomalies. Fourteen similar-appearing localized hyperkeratotic vascular lesions were identified by one surgeon as either angiokeratoma, angiokeratoma circumscriptum, capillary-venous malformation, capillary-lymphatic malformation, or verrucous hemangioma. All lesions were located on an extremity, except for one lesion on the trunk, and were single or grouped and 2.6 to 8 cm in diameter. All were raised, red-to-purple, variably keratotic with irregular borders, and several manifested intermittent bleeding and oozing. Excision was performed at 4 months to 16 years of age. After histologic review, three lesions were designated as combined vascular malformations composed of capillaries, lymphatics, and veins, and none was designated as angiokeratoma. Eleven of 14 specimens met the histologic criteria for verrucous hemangioma: a hyperkeratotic epidermis with small, thick-walled, blood-filled vessels with multilamellated basement membrane involving the entire dermis as well as the subcutis. Immunostaining showed focal GLUT1 endothelial positivity (7/11) and low-level MIB-1 reactivity (8/11). Verrucous hemangioma has the accepted clinical features of vascular malformation, specifically presence at birth and proportionate growth. Microscopic features, such as thick vascular walls, multilamellated basement membrane, relatively uniform channel size, and GLUT1 immunopositivity are reminiscent of infantile hemangioma, particularly in its involutive phase. No firm conclusion seems possible as to whether verrucous hemangioma is a malformation or an indolent tumor, but clinical evidence favors the former category.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Verrucous Hemangioma Revisited

Tennant¹,

Mulliken

Perez‐Atayde³

et al. 2006

Pediatric Dermatology

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show abstract

“…VERRUCOUS HEMANGIOMA (VH) is a rare entity that presents as circumscribed, warty papules or plaques or in a linear or serpiginous configuration. 1,2 The term VH was first coined by Halter 3 in 1937 to report a 16-year-old boy presenting with a linear, purpuric cluster of plaques extending from the right buttock to the toes and associated with shortening and atrophy of the affected limb. Several studies have described similar lesions using various names, including angiokeratoma circumscriptum naeviforme, 4 angiokeratoma circumscriptum, 5,6 angiokeratoma corporis naeviforme, 7 and keratotic hemangioma.…”

mentioning

confidence: 99%

“…VERRUCOUS HEMANGIOMA (VH) is a rare entity that presents as circumscribed, warty papules or plaques or in a linear or serpiginous configuration 1,2 . The term VH was first coined by Halter 3 in 1937 to report a 16‐year‐old boy presenting with a linear, purpuric cluster of plaques extending from the right buttock to the toes and associated with shortening and atrophy of the affected limb.…”

mentioning

confidence: 99%