Unilateral hyperkeratosis lenticularis perstans (Flegel’s disease)

Hyperkeratosis lenticularis perstans (Flegel’s Disease) – Lack of Response to Treatment with Tacalcitol and Calcipotriol

“…However, it remains questionable whether oral retinoids are justified for a long-term therapy of a benign asymptomatic condition. Topical retinoids have not been consistently effective [12, 21]. Topical 5-fluorouracil cream seems to be most effective for HLP [3, 6, 23]as confirmed in our patient.…”

“…Lesions of HLP have also been reported involving the arms, palms, soles and oral mucosa [8, 9]. Removal of the adherent horny scale above each papule often causes pinpoint bleeding [8, 10, 11, 12]. …”

Histopathological Differences Between Early and Old Lesions of Hyperkeratosis Lenticularis Perstans (Flegel's Disease)

“…2 Removal of the spiny scale above each papule causes slight bleeding. [2][3][4][5][6][7][8][9][10][11][12][13] Although HLP has been considered an autosomal dominant condition, [14][15][16] most cases seem to occur sporadically and usually start in late adult life. 2,4,5,8,[10][11][16][17][18][19] HLP can be clearly distinguished from clinically similar disorders such as Kyrle's disease, porokeratosis and stucco keratosis by its characteristic histologic features.…”

Ein Fall von lokalisierter, unilateraler Hyperkeratosis lenticularis perstans an der Brust einer Frau

“…Seltener wurde von Läsionen in den Achselfalten, Ellenbeugen, Kniekehlen, und an den Augenlidern berichtet, zusätzlich zu der häufigeren Beteiligung von Beinen und Händen [6]. Ein Fall mit unilateralen Läsionen an der unteren Extremität, die seit der Pubertät existierten, ist ebenfalls beschrieben worden [7]. Histopathologische Befunde zeigen typischerweise eine orthokeratotische und hyperkeratotische Epidermis mit verminderter Dicke.…”