Unilateral giant peripapillary drusen and retinal drusenoid deposits in a case of X-linked retinoschisis

Tripathy, Koushik; Chawla, Rohan; Meena, Seema; Agarwal, P. C.

doi:10.1136/bcr-2016-214558

Cited by 4 publications

(2 citation statements)

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“…Abnormalities of axonal metabolism, or abnormalities of axonal transport, have been suggested as precursors of ONHD, but without hypotheses to explain why axoplasmic flow is impaired. 2,19,23,24,46,148,149 It is worth noting that metabolic optic neuropathies such as mitochondrial diseases, toxic or nutritional optic neuropathies, all affect the optic nerve in a different way to ONHD with bilateral loss of acuity, central scotoma, and loss of colour vision. That is, the temporal disc and papillomacular bundle are first affected in metabolic disorders and spared in ONHD, glaucoma, and papilloedema.…”

Section: Abnormal Axonal Metabolismmentioning

confidence: 99%

Optic Nerve Head Drusen: An Update

Palmer

Gale

Crowston

et al. 2018

Neuro-Ophthalmology

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Optic nerve head drusen are benign acellular calcium concretions that usually form early in life, just anterior to the lamina cribrosa. Improving imaging using optical coherence tomography suggests they are common and may be present in many clinically normal discs. These drusen may change in appearance in early life, but are generally stable in adulthood, and may be associated with visual field defects, anterior ischaemic optic neuropathy, or rarer complications. Based on long-term clinical data and optical coherence tomography, we propose a refined hypothesis as to the cause of optic disc drusen. Here we summarise recent findings and suggest future studies to better understand the forces involved.

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Section: Abnormal Axonal Metabolismmentioning

confidence: 99%

Optic Nerve Head Drusen: An Update

Palmer

Gale

Crowston

et al. 2018

Neuro-Ophthalmology

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“… Bilateral hyporeflective spaces in macular optical coherence tomography in a young male may also be noted in juvenile retinoschisis or X-linked retinoschisis (XLRS),[ 2 ] and peripheral retinoschisis may be absent in 50% of such cases. The fovea in magnified pictures of Fig.…”

mentioning

confidence: 99%

Comment on: “Multimodal imaging in dominant cystoid macular dystrophy”

Tripathy

2018

Indian J Ophthalmol

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Phthisis Bulbi—a Clinicopathological Perspective

Tripathy

Chawla

Temkar

et al. 2018

Seminars in Ophthalmology

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Phthisis bulbi denotes end-stage eye disease characterized by shrinkage and disorganization of the eye with the resultant functional loss. The major factors associated with the pathogenesis of phthisis are hypotony, deranged blood-ocular barriers, and inflammation. Common causes include trauma, surgery, infection, inflammation, malignancy, retinal detachment, and vascular lesions. A phthisical globe shows a small squared off shape, opaque and thickened cornea, thickened sclera, neovascularization of iris, cataract, cyclitic membrane, ciliochoroidal detachment, and retinal detachment. Microscopic features include internal disorganization, inflammatory reaction, a reactive proliferation of various cells, calcification, and ossification. Early treatment of the causative etiology is the best strategy available to avoid an eye from going into phthisis. A phthisical eye has no visual potential and cosmetic rehabilitation or symptomatic relief of pain remains the mainstay in the management. The authors present a comprehensive review of the etiopathogenesis, pathology, clinical features, and management of the end-stage ocular disease.

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Unilateral giant peripapillary drusen and retinal drusenoid deposits in a case of X-linked retinoschisis

Cited by 4 publications

References 4 publications

Optic Nerve Head Drusen: An Update

Optic Nerve Head Drusen: An Update

Comment on: “Multimodal imaging in dominant cystoid macular dystrophy”

Phthisis Bulbi—a Clinicopathological Perspective

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