Unilateral Giant Bullous Emphysema With Placental Transmogrification of the Lung

Horsley, William; Gal, Anthony A.; Mansour, Kamal A.

doi:10.1016/s0003-4975(97)00274-9

Cited by 26 publications

(30 citation statements)

References 2 publications

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“…Grossly, the PTL resembles a placenta or cystic lesions [1][2][3][4][5][6][7]. These areas are replaced or filled by gelatinous tissues described as bubbly, vesicular, grape-like or spongelike.…”

Section: Discussionmentioning

confidence: 99%

“…These cells were immunoreactive for CD-10 and vimentin. These findings characterize the PTL [1][2][3][4].…”

Section: Case Reportmentioning

confidence: 99%

“…The patients ranged in age from 25 to 60 years and typically presented with dyspnea, thoracic pain and/or pneumothorax. Radiographically, PTL usually presents as a bullous lesion and rarely as a cyst or nodule, and surgical resection is the treatment of choice [3,4]. Grossly, PTL resembles a placenta, and microscopically it is filled with papillary structures covered by epithelial cells, like a placental villi [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Placental transmogrification of the lung presenting as giant bullae with soft-fatty components

Santana

Canzian

Stelmach

et al. 2008

European Journal of Cardio-Thoracic Surgery

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A 44-year-old man presented with progressive dyspnea and a previous pneumothorax. Chest CT scan showed a mediastinal shift due to giant bullae containing soft tissue and fatty components in the left lower lung lobe, and a right upper lung lobe partially collapsed. The pulmonary function tests revealed forced vital capacity (FVC) 53% (of the predicted) and forced vital capacity in 1s (FEV1) 52%. Then, resection of the lower lobe was performed with intention to prevent other pneumothoraxes and to revert the upper lobe collapse. The pathological examination showed a placental transmogrification of the lung (PTL). One month after the surgery, the patient was asymptomatic, the pulmonary function tests normalized and the upper lobe was well expanded. In conclusion, we described the first CT finding of soft tissue and fatty components within the PTL-related bullae, and the PTL should be considered in the differential diagnosis of pulmonary lesions with soft-fatty and air components.

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Section: Discussionmentioning

confidence: 99%

“…These cells were immunoreactive for CD-10 and vimentin. These findings characterize the PTL [1][2][3][4].…”

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Placental transmogrification of the lung presenting as giant bullae with soft-fatty components

Santana

Canzian

Stelmach

et al. 2008

European Journal of Cardio-Thoracic Surgery

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show abstract

“…First described in abstract form in 1979, 6 PT represents a rare disease, with only 15 cases reported in the literature to date. [2][3][4][5][6][7][8][9][10][11] The clinical data for these 15 cases are summarized in Table 2.…”

Section: Discussionmentioning

confidence: 99%

Placental transmogrification of the lung: clinicopathologic, immunohistochemical and molecular study of two cases, with particular emphasis on the interstitial clear cells

et al. 2004

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“…Histologic section of the resected lung specimen showed frondlike structures with central hyaline cores and ectatic vessels, resembling chorionic villi (placental transmogrification). [1][2][3][4][5][6] The postsurgical course was uneventful and the patient was discharged 5 days later.…”

Section: Figurementioning

confidence: 99%

Transmogrification of Lung: A Rare Entity of Bullous Emphysema Assessed by Perfusion Scintigraphy

Khoury¹,

Jerushalmi²,

Zaina³

et al. 2004

Clinical Nuclear Medicine

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Placental transmogrification of the lung (PTL) is a rare, benign cystic disease of the lung, first described in 1979, that occurs in association with bullous emphysema and involves a single lobe of the lung. Few cases have been reported in the medical literature. Macroscopic and histologic findings of the disease resemble those of placental villi. The pathogenesis of PTL is unknown. Most authors believe that the condition develops from or is a reaction to emphysema. Some suggest that the lesion is related to a lymphatic or vascular abnormality in emphysematous lung parenchyma. An association of the disease with pulmonary fibrochondromatous hamartomas and other pulmonary diseases has been reported. The presentation of the disease is variable and it ranges from asymptomatic to varying degrees of respiratory ailments including respiratory distress in the extreme cases. Rarely this lesion has been discovered incidentally on radiography or CT scan. Surgical resection is the usual curative treatment. The authors report the case of a 36-year-old man with a giant bulla of the upper lobe of the right lung. Microscopic examination of the resected specimen revealed the typical histologic features of placental transmogrification. The patient was assessed with quantitative perfusion lung scintigraphy both before and after lung volume reduction surgery.

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Unilateral Giant Bullous Emphysema With Placental Transmogrification of the Lung

Cited by 26 publications

References 2 publications

Placental transmogrification of the lung presenting as giant bullae with soft-fatty components

Placental transmogrification of the lung presenting as giant bullae with soft-fatty components

Placental transmogrification of the lung: clinicopathologic, immunohistochemical and molecular study of two cases, with particular emphasis on the interstitial clear cells

Transmogrification of Lung: A Rare Entity of Bullous Emphysema Assessed by Perfusion Scintigraphy

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