Unilateral F-18 FDG Uptake in the Neck, in Patients With Sympathetic Denervation

Lebron, Lizza; Chou, Alexander J.; Carrasquillo, Jorge A.

doi:10.1097/rlu.0b013e3181f49ff8

Cited by 14 publications

(13 citation statements)

References 8 publications

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“…Emotional hyperthermia also occurs in humans, as first convincingly demonstrated by Renbourn (48). BAT thermogenesis occurs in adult humans and is under sympathetic control (30,41,42,50,59). Human basal metabolic rate is particularly sensitive to emotionally significant or salient events (19).…”

Section: Perspectives and Significancementioning

confidence: 99%

Brown adipose tissue thermogenesis contributes to emotional hyperthermia in a resident rat suddenly confronted with an intruder rat

Mohammed

Ootsuka

Blessing

2014

American Journal of Physiology-Regulatory, Integrative and Comp

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There is controversy concerning the contribution of nonshivering thermogenesis in brown adipose tissue (BAT) to emotional hyperthermia. In the present study we compared BAT, core body, and brain temperature, and tail blood flow, simultaneously measured, to determine whether BAT thermogenesis contributes to emotional hyperthermia in a resident Sprague-Dawley rat when an intruder rat, either freely-moving or confined to a small cage, is suddenly introduced into the cage of the resident rat for 30 min. Introduction of the intruder rat promptly increased BAT, body, and brain temperatures in the resident rat. For the caged intruder these temperature increases were 1.4 Ϯ 0.2, 0.8 Ϯ 0.1, 1.0 Ϯ 0.1°C, respectively, with the increase in BAT temperature being significantly greater (P Ͻ 0.01) than the increases in body and brain. The initial 5-min slope of the BAT temperature record (0.18 Ϯ 0.02°C/min) was significantly greater (P Ͻ 0.01) than the corresponding value for body (0.10 Ϯ 0.01°C/min) and brain (0.09 Ϯ 0.02°C/min). Tail artery pulse amplitude fell acutely when the intruder rat was introduced, possibly contributing to the increases in body and brain temperature. Prior blockade of ␤3 adrenoceptors (SR59230A 10 mg/kg ip) significantly reduced the amplitude of each temperature increase. Intruder-evoked increases in BAT temperature were similar in resident rats maintained at 11°C for 3 days. In the caged intruder situation there is no bodily contact between the rats, so the stimulus is psychological rather than physical. Our study thus demonstrates that BAT thermogenesis contributes to increases in body and brain temperature occurring during emotional hyperthermia. body temperature; brain temperature; cutaneous blood flow; stressinduced hyperthermia; fever IN MAMMALS, BIRDS, AND REPTILES, body temperature may increase when individuals are placed in salient, emotionally significant situations, those relevant to the life and survival of the individual, a response sometimes referred to as "stressinduced hyperthermia" or "psychological fever" (5,8,18,31,32,35,40,44,60). The amplitude of the stress-related body temperature increase is similar in animals maintained at thermoneutrality or in a cold environment, so the response is not simply secondary to increased metabolism in skeletal and cardiac muscle. Rather, the temperature increases are initiated from the brain via active central command, supplementing homeostatic thermoregulatory processes. This is readily apparent when a lizard behaviorally increases its temperature by selecting a hotter environment after being released from manual restraint (10). In mammals, salient, emotionally arousing events also trigger vasoconstriction in the thermoregulatory cutaneous vascular beds, potentially contributing to emotional hyperthermia by reducing heat loss from the body (for references see Ref. 36).Most mammals have the capacity for facultative (nonshivering) thermogenesis such as that generated in brown adipose tissue (BAT), and heat produced by BAT is important for thermoregu...

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Section: Perspectives and Significancementioning

confidence: 99%

Brown adipose tissue thermogenesis contributes to emotional hyperthermia in a resident rat suddenly confronted with an intruder rat

Mohammed

Ootsuka

Blessing

2014

American Journal of Physiology-Regulatory, Integrative and Comp

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“…First, the uptake of the sympathetic tracers 123 I-mIBG and 6-18 F-FDA in BAT [27,31,33] and, second, interruption of the sympathetic nerves innervating BAT diminishes its metabolic activity [24,40]. Third, ␤-and ␣-adrenergic receptor blockade are highly successful pretreatment strategies for reducing BAT activity [28,29,[42][43][44][45].…”

Section: Conclusion: Clinical Impact and Future Considerationsmentioning

confidence: 98%

“…This is clearly described in a small case series of two patients with Horner's syndrome and one patient who had undergone surgical sympathectomy. All patients showed unilateral uptake of 18 F-FDG in BAT on PET-CT on the unaffected side, but not on the side of interruption of the cervical/thoracic sympathetic chain [40].…”

Section: Interruption Of Sympathetic Nervesmentioning

confidence: 98%

Role of the autonomic nervous system in activation of human brown adipose tissue: A review of the literature

Bahler

Molenaars

Verberne

et al. 2015

Diabetes & Metabolism

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“…Playing a role in thermoregulation process thanks to a specific messenger protein, i.e. uncoupling protein one (UCP1), BAT can be affected by several different factors, for example gender (Cypess et al, 2009), age (Heaton, 1972) or exposure to temperature variations (Cypess et al, 2009;van Marken Lichtenbelt et al, 2009;Saito et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Imaging and identification of brown adipose tissue on CT scan

Prodhomme

Robin

Alavi

et al. 2016

Clin Physio Funct Imaging

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Two types of adipose tissue (AT) have been described in the field of physiology: white (W) and brown (B) AT. Although WAT is well identified on human imaging, BAT imaging aspect remains to be further explored. The aim of this study was to investigate imaging aspect of BAT and its identification on CT (computed tomography) with iodine-based contrast media injection. We retrospectively reviewed 464 positron emission tomography (PET)/CT, performed during 21 months on adults younger than 37 years. In 39 cases only, the PET revealed the presence of activated BAT. ROI was placed on both white and brown adipose tissue simultaneously on both PET and CT. Several patients' characteristics (blood sugar level, gender, age, body mass index) as well as BAT and WAT parameters were assessed. Mean CT densities for WAT and BAT were -99·5 HU versus -32·6, mean SUV were 1·38 versus 13·2 and SUVmax were 1·79 versus 16·57, respectively. We found a statistically significant inverse relation between BMI and BAT density. BAT has a higher density than WAT. In this manner, BAT can be misinterpreted as an infiltration of adipose tissue in neoplasic and inflammatory context. Contrast-enhanced CT scan allows visualization and identification of BAT.

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Unilateral F-18 FDG Uptake in the Neck, in Patients With Sympathetic Denervation

Cited by 14 publications

References 8 publications

Brown adipose tissue thermogenesis contributes to emotional hyperthermia in a resident rat suddenly confronted with an intruder rat

Brown adipose tissue thermogenesis contributes to emotional hyperthermia in a resident rat suddenly confronted with an intruder rat

Role of the autonomic nervous system in activation of human brown adipose tissue: A review of the literature

Imaging and identification of brown adipose tissue on CT scan

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