Unilateral contractions modulate interhemispheric inhibition most strongly and most adaptively in the homologous muscle of the contralateral limb

Hinder, Mark R.; Schmidt, Matthew; Garry, Michael I.; Summers, Jeffery J.

doi:10.1007/s00221-010-2379-z

Cited by 66 publications

(87 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent work from Fujiyama et al (2012a, b) reports that an increased capacity to regulate inhibitory function was positively associated with better performance levels in older adults. It is noteworthy that previous studies already showed that preparatory suppression might be manifested at the cortical level, including inhibitory processes in the contralateral motor area (Duque et al 2007;Hinder et al 2010;Talelli et al 2008). Additionally, the involvement of higher order motor areas such as the dorsal premotor cortex cannot be ruled out (Duque et al 2012).…”

Section: Discussionmentioning

confidence: 92%

Age-related differences in corticospinal excitability during a choice reaction time task

Cuypers

Thijs

Duqué

et al. 2012

AGE

View full text Add to dashboard Cite

Age-related declines in central processing may affect corticospinal (CS) excitability that underlies the emergence of voluntary responses to external stimuli. We used single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex to explore the evolution of CS excitability in 14 young and ten elderly healthy right-handed participants. Motor-evoked potentials (MEPs) were elicited in the right or left first dorsal interosseus (FDI) during the preparatory and premotor periods of a choice reaction time (CRT) task, which required selection of left or right index finger responses. Both age groups showed significant suppression of CS excitability in the preparatory period. However, suppression was generally less pronounced in older than in young adults. Moreover, our data indicated that a reduced suppression in the right FDI during the preparatory period was associated with longer reaction times (RTs) in older adults only. In the premotor period, both age groups demonstrated comparable facilitation levels towards movement onset. Our findings indicate that increased RTs among older individuals could be directly associated with declines in preparatory processes.

show abstract

Section: Discussionmentioning

confidence: 92%

Age-related differences in corticospinal excitability during a choice reaction time task

Cuypers

Thijs

Duqué

et al. 2012

AGE

View full text Add to dashboard Cite

show abstract

“…Meanwhile, it has also been reported that marked IHI was evident when a CS was applied to the dominant M1 innervating the dominant hand during the resting state (Baumer et al 2007). Hinder et al (2010) and Vercauteren et al (2008) evaluated the IHI of the Lt-hand during the performance of a simple voluntary contraction task with the dominant Rt-hand (opposite to the conditions studied here). Thus there is a possibility that hemispheric asymmetry affects the degree of IHI during the active state.…”

Section: Discussionmentioning

confidence: 97%

“…1992; Hinder et al 2010;Talleli et al 2008;Vercauteren et al 2008). Ferbert et al (1992) first reported that unilateral simple voluntary contraction of the Lt-FDI resulted in weakly, but significantly, increased IHI from the active to the resting M1.…”

Section: Discussionmentioning

confidence: 99%

“…As described above, several studies have investigated the effect of performing unilateral hand motor tasks on IHI from the active to the resting M1. However, these studies had methodological issues, i.e., some of them adjusted the CS intensity to evoke the same MEP amplitude in the active muscle (Nelson et al 2009(Nelson et al , 2010Perez and Cohen 2008) whereas others did not (Ferbert et al 1992;Hinder et al 2010;Talelli et al 2008;Vercauteren et al 2008). Perez and Cohen (2008) reported that the IHI from the active to the resting M1 was reduced during simple unilateral hand motor tasks at force levels ranging from 10% to 70% of MVC when the CS intensity was adjusted.…”

Section: Discussionmentioning

confidence: 99%

“…It is considered that IHI might play a crucial role in suppressing involuntary contralateral activity and assist in the coordination of bimanual hand motor tasks (Duque et al 2005(Duque et al , 2007Hubers et al 2008). In accordance with this view, several studies have investigated the effects of performance of unilateral hand motor tasks on the IHI induced from the active to the resting M1, and it was found that unilateral hand motor tasks moderately increase the IHI induced from the active to the resting M1 (Ferbert et al 1992;Hinder et al 2010;Talelli et al 2008;Vercauteren et al 2008).…”

mentioning

confidence: 89%

See 2 more Smart Citations

Changes in interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task

Morishita

Uehara

Funase

2012

Journal of Neurophysiology

View full text Add to dashboard Cite

Morishita T, Uehara K, Funase K. Changes in interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task. J Neurophysiol 107: 3086 -3094, 2012. First published March 14, 2012 doi:10.1152/jn.00888.2011.-The effect of performance of a sensorimotor task on the interhemispheric inhibition (IHI) induced from the active primary motor cortex (M1) to the resting M1 was examined in 10 right-handed subjects. Transcranial magnetic stimulation (TMS) was performed to produce motor evoked potentials (MEP) in the resting right (Rt)-first dorsal interosseous (FDI). For the paired-TMS paradigm, a conditioning stimulus (CS) was delivered to the Rt-M1, and its intensity was adjusted from 0.6 to 1.4 times the resting motor threshold of the MEP in the left (Lt)-FDI in 0.2 steps. The test stimulus was delivered to the Lt-M1, and its intensity was adjusted to evoke similar MEP amplitudes in the Rt-FDI among the task conditions. The interstimulus interval was fixed at 10 ms. As a sensorimotor task, a fine-motor manipulation (FM) task (using chopsticks to pick up, transport, and release glass balls) was adopted. In addition, an isometric abduction (IA) task was also performed as a control task. These tasks were carried out with the left hand. The IHI from the active to the resting M1 observed during the FM task was markedly increased compared with that induced during the IA task, and this effect was not dependent on the MEP amplitude evoked in the active Lt-FDI by the CS. The present findings suggest that the increased IHI from the active to the resting M1 observed during the FM task was linked to reductions in the activity of the ipsilateral intracortical inhibitory circuit, as we reported previously.

show abstract

Does abnormal interhemispheric inhibition play a role in mirror dystonia?

et al. 2013

View full text Add to dashboard Cite

The presence of mirror dystonia (dystonic movement induced by a specific task performed by the unaffected hand) in the dominant hand of writer's cramp patients when the nondominant hand is moved suggests an abnormal interaction between the 2 hemispheres. In this study we compare the level of interhemispheric inhibition (IHI) in 2 groups of patients with writer's cramp, one with the presence of a mirror dystonia and the other without as well as a control group. The level of bidirectional IHI was measured in wrist muscles with dual-site transcranial magnetic stimulation with a 10-millisecond (short IHI) and a 40-millisecond (long IHI) interstimulus interval during rest and while holding a pen in 9 patients with mirror dystonia 7 without mirror dystonia, and 13 controls. The group of patients without mirror dystonia did not differ from the controls in their IHI level. In contrast, IHI was significantly decreased in the group of patients with mirror dystonia in comparison with the group without mirror dystonia and the controls in both wrist muscles of both the dystonic and unaffected hand whatever the resting or active condition (P = 0.001). The decrease of IHI level in the group of patients with mirror dystonia was negatively correlated with the severity and the duration of the disease: the weaker the level of IHI, the more severe was the disease and the longer its duration. Interhemispheric inhibition disturbances are most likely involved in the occurrence of mirror dystonia. This bilateral deficient inhibition further suggests the involvement of the unaffected hemisphere in the pathophysiology of unilateral dystonia.

show abstract

Unilateral contractions modulate interhemispheric inhibition most strongly and most adaptively in the homologous muscle of the contralateral limb

Cited by 66 publications

References 29 publications

Age-related differences in corticospinal excitability during a choice reaction time task

Age-related differences in corticospinal excitability during a choice reaction time task

Changes in interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task

Does abnormal interhemispheric inhibition play a role in mirror dystonia?

Contact Info

Product

Resources

About