Unilateral cerebellar stroke disrupts movement preparation and motor imagery

Battaglia, Fortunato; Quartarone, Angelo; Ghilardi, Maria Felice; Dattola, R.; Bagnato, Sergio; Rizzo, Vincenzo; Morgante, Francesca; Girlanda, Paolo

doi:10.1016/j.clinph.2006.01.008

Cited by 59 publications

(31 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further evidence of the role of the cerebellum in modulating cortical excitability comes from a recent study by Battaglia et al (2006). In patients with cerebellar stroke, these authors demonstrated decreasing excitability of motor cortex contralateral to the cerebellar lesion during preparation and imaging of sequential movements.…”

Section: Discussionmentioning

confidence: 97%

Changes in Cerebello-motor Connectivity during Procedural Learning by Actual Execution and Observation

Torriero

Oliveri

Koch

et al. 2011

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

Abstract■ The cerebellum is involved in motor learning of new procedures both during actual execution of a motor task and during observational training. These processes are thought to depend on the activity of a neural network that involves the lateral cerebellum and primary motor cortex (M1). In this study, we used a twin-coil TMS technique to investigate whether execution and observation of a visuomotor procedural learning task is related to modulation of cerebello-motor connectivity. We observed that, at rest, a magnetic conditioning pulse applied over the lateral cerebellum reduced the motor-evoked potentials obtained by stimulating the contralateral M1, indicating activation of a cerebello-motor connection. Furthermore, during procedural learning, cerebellar stimulation resulted in selective facilitation, not inhibition, of contralateral M1 excitability. The effects were evident when motor learning was obtained by actual execution of the task or by observation, but they disappeared if procedural learning had already been acquired by previous observational training. These results indicate that changes in cerebello-motor connectivity occur in relation to specific phases of procedural learning, demonstrating a complex pattern of excitatory and inhibitory drives modulated across time. ■

show abstract

Section: Discussionmentioning

confidence: 97%

Changes in Cerebello-motor Connectivity during Procedural Learning by Actual Execution and Observation

Torriero

Oliveri

Koch

et al. 2011

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

show abstract

“…Examples are silent word generation and counting, tennis training movements, and the observation or imagination of grasping movements (Battaglia et al, 2006;Kuhtz-Buschbeck et al, 2003;Ross, Tkach, Ruggirei, Lieber, & Lapresto, 2003;Petersen, van Mier, Fiez, & Raichle, 1998;Thach, 1996Thach, , 1998Decety & Ingvar, 1990). Positron emission tomography data report cerebellar activation during observation of meaningful and meaningless actions for the purpose of imitation and, conversely, no cerebellar activation during the mere observation of meaningless actions (Leslie, Johnson-Frey, & Grafton, 2004;Chaminade, Meltzoff, & Decety, 2002;Grèzes & Decety, 2001Decety & Grèzes, 1999;Decety et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

The What and How of Observational Learning

Torriero

Oliveri

Koch

et al. 2007

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

Abstract& Neuroimaging evidence increasingly supports the hypothesis that the same neural structures subserve the execution, imagination, and observation of actions. We used repetitive transcranial magnetic stimulation (rTMS) to investigate the specific roles of cerebellum and dorsolateral prefrontal cortex (DLPFC) in observational learning of a visuomotor task. Subjects observed an actor detecting a hidden sequence in a matrix and then performed the task detecting either the previously observed sequence or a new one. rTMS applied over the cerebellum before the observational training interfered with performance of the new sequence, whereas rTMS applied over the DLPFC interfered with performance of the previously observed one. When rTMS applied over cerebellar or prefrontal site was delivered after the observational training, no influence was observed on the execution of the task. These results furnish new insights on the neural circuitry involved in the single component of observational learning and allow us to hypothesize that cerebellum and DLPFC interact in planning actions, the former by permitting the acquisition of procedural competencies and the latter by providing flexibility among already acquired solutions. &

show abstract

“…Fig. 1 suggests that the representative ataxia patient and control subject show an increased difference in power in the mu-band (8)(9)(10)(11)(12), between relaxation and motor imagery. Darker shades of red represent an increase in power during the relaxation task over the motor imagery task at the same time point and frequency band within the trial.…”

Section: Resultsmentioning

confidence: 99%

“…In a study of people with unilateral cerebellar stroke, patients attempting motor imagery showed decreased motor evoked potential facilitation in the associated motor cortex [10]. In a second study, patients that had apparently recovered from a unilateral cerebellar stroke showed a marked slowing of motor performance in both hands (ipsi-and contralateral to lesion).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Motor Imagery based Brain-Computer Interface for Cerebellar Ataxia

Choi¹,

Shin²,

Ying³

et al. 2014

Journal of Korean Institute of Intelligent Systems

View full text Add to dashboard Cite

Cerebellar ataxia is a steadily progressive neurodegenerative disease associated with loss of motor control, leaving patients unable to walk, talk, or perform activities of daily living. Direct motor instruction in cerebella ataxia patients has limited effectiveness, presumably because an inappropriate closed-loop cerebellar response to the inevitable observed error confounds motor learning mechanisms. Recent studies have validated the age-old technique of employing motor imagery training (mental rehearsal of a movement) to boost motor performance in athletes, much as a champion downhill skier visualizes the course prior to embarking on a run. Could the use of EEG based BCI provide advanced biofeedback to improve motor imagery and provide a "backdoor" to improving motor performance in ataxia patients? In order to determine the feasibility of using EEG-based BCI control in this population, we compare the ability to modulate mu-band power (8-12 Hz) by performing a cued motor imagery task in an ataxia patient and healthy control.

show abstract

Unilateral cerebellar stroke disrupts movement preparation and motor imagery

Cited by 59 publications

References 61 publications

Changes in Cerebello-motor Connectivity during Procedural Learning by Actual Execution and Observation

Changes in Cerebello-motor Connectivity during Procedural Learning by Actual Execution and Observation

The What and How of Observational Learning

Motor Imagery based Brain-Computer Interface for Cerebellar Ataxia

Contact Info

Product

Resources

About