Unilateral benign yellow dot maculopathy

Abstract

Purpose To describe a unique case of unilateral benign yellow dot maculopathy. Observations A 25-year-man was evaluated after incidental finding of yellow dots in the right macula. The findings of examination and multimodal imaging were in keeping with a diagnosis of benign yellow dot maculopathy. Conclusions and importance Benign yellow dot maculopathy is a recently described entity with either a sporadic or dominant inheritance pattern. This is the first known report of the characteristic findings of this phenotype presenting unilaterally.

High-Resolution Spectral Domain Optical Coherence Tomography of Congenital Grouped Albinotic Spots

“…On multimodal imaging, CGAS shared overlapping features with benign yellow dot maculopathy and Kandori fleck retina, suggesting that these disorders may form a continuous spectrum of similar RPE abnormalities. 3 Although histologic correlation has not been reported, it is speculated that CGAS result from impaired melanogenesis of RPE cells. 1 Alternatively, CGAS could result from RPE lipoidal degeneration, an intracellular lipid droplet accumulation seen as pale yellow fundus spots without RPE elevation.…”