Unilateral Acute Anterior Ischemic Optic Neuropathy in a Patient with an Already Established Diagnosis of Bilateral Optic Disc Drusen

Ayhan, Zi̇ya; Yaman, Aylın; Bajin, Meltem Söylev; Saatçi, Ali Osman

doi:10.1155/2015/730606

Cited by 10 publications

(8 citation statements)

References 21 publications

(13 reference statements)

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“…Regarding ODD and prelaminar hyperreflective lines, this is unlikely for several reasons: (1) Previous case reports and one larger follow-up study have described cases of presence of ODD before onset of NA-AION years later. 28,29 (2) ODD is believed to be inherited in an irregular autosomal dominant manner. 30 (3) Studies have found patients with ODDassociated NA-AION (ODD-AION) to be younger than NA-AION patients, indicating ODD being an independent risk factor to NA-AION.…”

Section: Discussionmentioning

confidence: 99%

OCT based interpretation of the optic nerve head anatomy in young adults with retinal vascular occlusions and ischemic optic neuropathy

Dai

Malmqvist

Rothenbuehler

et al. 2020

European Journal of Ophthalmology

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Purpose: To examine optic nerve head (ONH) anatomy in young adults with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) or nonarteritic anterior ischemic optic neuropathy (NA-AION) in order to look for associated, potentially predisposing anomalies. Methods: Cross-sectional study including 54 patients (ages 16–50 years) diagnosed from 2009 to 2018 with CRVO, BRVO, CRAO, BRAO, or NA-AION. Using Optical Coherence Tomography the presence of optic disc drusen (ODD), prelaminar hyperreflective lines and peripapillary hyperreflective ovoid mass-like structures (PHOMS), and determination of scleral canal size, retinal nerve fiber layer thickness (RNFLT) and macular ganglion cell layer thickness (GCLT) was obtained. Data for retinal vascular occlusion patients were grouped and analyzed together. Results: ODD were found in 13% of all patients, 2% of retinal vascular occlusion patients and 67% of NA-AION patients ( p < 0.0001). Prelaminar hyperreflective lines were found in 35% of all patients, 24% of retinal vascular occlusion patients and 89% of NA-AION patients ( p = 0.0005). PHOMS were found in 20% of all patients, 13% of retinal vascular occlusion patients and 56% of NA-AION patients ( p = 0.012). RNFLT was decreased in ODD patients compared to patients without ODD ( p = 0.01). Scleral canal diameter and GCLT was not correlated with ODD, prelaminar hyperreflective lines or PHOMS. Conclusion: ODD, prelaminar hyperreflective lines and PHOMS were more frequent in NA-AION patients compared to retinal vascular occlusion patients. The prevalence of ODD in retinal vascular occlusion patients was similar to the reported prevalence in the general population.

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Section: Discussionmentioning

confidence: 99%

OCT based interpretation of the optic nerve head anatomy in young adults with retinal vascular occlusions and ischemic optic neuropathy

Dai

Malmqvist

Rothenbuehler

et al. 2020

European Journal of Ophthalmology

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“…Though quite rare, NAION, central retinal artery and vein occlusion have been reported to occur in cases with ONHD. [13][14][15][16][17][18][19][20][21] The exact mechanism by which ONHD causes NAION is uncertain. By tightening the disc space drusen can increase the susceptibility to optic nerve head ischemia.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16][17][18][19][20] The recent published cases have additional risk factors such as diabetes mellitus that could cause NAION apart from ONHD. 21 It is therefore very difficult to directly associate ONHD with NAION. Our report has two contributions to the literature.…”

Section: Discussionmentioning

confidence: 99%

Acute Unilateral Anterior Ischemic Optic Neuropathy Secondary to Optic Nerve Head Drusen: Report of a Rare Coexistence

Kartı

Karti

Zengin

et al. 2018

Neuro-Ophthalmology

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A 45-year-old white male noticed on awakening the painless loss of inferior vision in the left eye 2 days ago. He was otherwise well and his medical history was unremarkable. Visual acuity was 20/20 in OD and 20/32 in OS with a left inferior altitudinal defect and right blind spot enlargement demonstrable on visual field test. On fundus examination, both disc margins were blurred and the left disc was diffusely oedematous, with linear haemorrhages in the adjacent nerve fibre layer. Radiologic imaging and laboratory tests were unremarkable. Bilateral optic nerve head drusen (ONHD) was demonstrated by optical coherence tomography and fundus autofluorescence imaging. Unilateral acute non-arteritic anterior ischemic optic neuropathy (NAION) and concomitant bilateral ONHD were diagnosed. NAION may develop secondary to ONHD. Therefore, clinicians should be aware of this rare association and inform the patients about this risk. Patients with ONHD should be followed-up periodically in terms of possible ischemic complications.

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“…Patients with ONHD appear to be at increased risk of non-arteritic anterior ischaemic optic neuropathy (NAION), although the risk is hard to quantify in this small and varied population. 24,123,124 Patients are typically younger and have more favourable outcomes than NAION patients without ONHD. Other risk factors for NAION and clinical features such as the risk of bilateral disease, and visual field defects are similar in those with or without ONHD.…”

Section: Anterior Ischaemic Optic Neuropathymentioning

confidence: 99%

Optic Nerve Head Drusen: An Update

Palmer

Gale

Crowston

et al. 2018

Neuro-Ophthalmology

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Optic nerve head drusen are benign acellular calcium concretions that usually form early in life, just anterior to the lamina cribrosa. Improving imaging using optical coherence tomography suggests they are common and may be present in many clinically normal discs. These drusen may change in appearance in early life, but are generally stable in adulthood, and may be associated with visual field defects, anterior ischaemic optic neuropathy, or rarer complications. Based on long-term clinical data and optical coherence tomography, we propose a refined hypothesis as to the cause of optic disc drusen. Here we summarise recent findings and suggest future studies to better understand the forces involved.

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Unilateral Acute Anterior Ischemic Optic Neuropathy in a Patient with an Already Established Diagnosis of Bilateral Optic Disc Drusen

Cited by 10 publications

References 21 publications

OCT based interpretation of the optic nerve head anatomy in young adults with retinal vascular occlusions and ischemic optic neuropathy

OCT based interpretation of the optic nerve head anatomy in young adults with retinal vascular occlusions and ischemic optic neuropathy

Acute Unilateral Anterior Ischemic Optic Neuropathy Secondary to Optic Nerve Head Drusen: Report of a Rare Coexistence

Optic Nerve Head Drusen: An Update

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