2000
DOI: 10.1021/ac0005215
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Uniform-Sized Molecularly Imprinted Polymers for 2-Arylpropionic Acid Derivatives Selectively Modified with Hydrophilic External Layer and Their Applications to Direct Serum Injection Analysis

Abstract: Uniform-sized molecularly imprinted polymers (MIPs) for (S)-naproxen and -ibuprofen selectively modified with hydrophilic external layer, restricted access media (RAM)-MIPs, have been prepared. First, the MIP for (S)-naproxen or -ibuprofen was prepared using 4-vinylpyridine and ethylene glycol dimethacrylate as a functional monomer and cross-linker, respectively, by a multistep swelling and thermal polymerization method. Next, a 1:1 mixture of glycerol monomethacrylate and glycerol dimethacrylate was used for … Show more

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Cited by 154 publications
(72 citation statements)
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“…The MIPs are used in several fields, such as sensors, catalysis, enantiomeric separation and SPE [3]. Nowadays, MIPs have been largely applied to the extraction or to clean up of target analytes from various complex matrices such environmental, biological, food and pharmaceuticals [4][5][6]. Concerning the pharmaceutical field, many examples deal with the extraction of a drug by MIP from tablets [7], plasma [8][9][10], serum [11], or from urine [12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…The MIPs are used in several fields, such as sensors, catalysis, enantiomeric separation and SPE [3]. Nowadays, MIPs have been largely applied to the extraction or to clean up of target analytes from various complex matrices such environmental, biological, food and pharmaceuticals [4][5][6]. Concerning the pharmaceutical field, many examples deal with the extraction of a drug by MIP from tablets [7], plasma [8][9][10], serum [11], or from urine [12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…[9][10][11][12][13] We prepared a restricted access media-MIP for naproxen and applied it to on-line MI-SPEs of ibuprofen in biological fluids. 14 Many chemicals released into the environment disrupt the endocrine system in wildlife and humans. 15 Bisphenol A (BPA) with a weak estrogenic activity is widely distributed in environmental fields and biological matrices.…”
Section: Introductionmentioning
confidence: 99%
“…O RAM-MIP foi empregado com sucesso na análise direta de (S)-naproxeno em amostras de soro [130] . Ainda nesta linha, o grupo sintetizou também um RAM-MIP empregando (S)-naproxeno ou ibuprofeno como molécula modelo, e os polí-meros obtidos foram utilizados na análise direta de amostras de soro através do sistema column--switching [131] . A metodologia foi empregada na obtenção de RAM-MIPs para análise de anti--inflamatórios não esteroidais, [132] antiepiléti-cos [133] e bisfenol-A [134] em amostras de água de rio.…”
Section: Extração Por Polímeros De Impressão Molecular Restritos à LIunclassified