Uniform-Sized Molecularly Imprinted Polymers for 2-Arylpropionic Acid Derivatives Selectively Modified with Hydrophilic External Layer and Their Applications to Direct Serum Injection Analysis

Haginaka, Jun; Sanbe, Haruyo

doi:10.1021/ac0005215

Cited by 154 publications

(72 citation statements)

References 20 publications

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“…The MIPs are used in several fields, such as sensors, catalysis, enantiomeric separation and SPE [3]. Nowadays, MIPs have been largely applied to the extraction or to clean up of target analytes from various complex matrices such environmental, biological, food and pharmaceuticals [4][5][6]. Concerning the pharmaceutical field, many examples deal with the extraction of a drug by MIP from tablets [7], plasma [8][9][10], serum [11], or from urine [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

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A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), from human urine. The synthesis of the MIP was performed in dimethylformamide with acrylamide as functional monomer, ethylene glycol dimethacrylate as the cross linker and ibuprofen template as the target drug. The performance of the synthesized MIP as solid phase extraction (SPE) packing to recognize and bind ibuprofen was evaluated against other structurally related NSAIDs such as naproxen and ketoprofen. Using a mixture of acetonitrile-water (1/9 v/v) as a solvent for ibuprofen the binding recovery at approximately 90% was obtained for developed MIP in optimized conditions. Batch rebinding capacity of ibuprofen was determined from the derived Freundlich isotherm and was found to be 1.45 mol g -1 . Furthermore, a higher selectivity of developed MIP for ibuprofen over structurally related analogues was observed. The synthesized MIP has enabled the direct percolation of humane urine and the easy elimination of endogenous compounds from it with simple aqueous washing of the MIP-SPE packing. HPLC analysis has confirmed the high extraction recovery (ca. 85 %) of ibuprofen from such urine samples with use of proposed MIP-SPE system.

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Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

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“…[9][10][11][12][13] We prepared a restricted access media-MIP for naproxen and applied it to on-line MI-SPEs of ibuprofen in biological fluids. 14 Many chemicals released into the environment disrupt the endocrine system in wildlife and humans. 15 Bisphenol A (BPA) with a weak estrogenic activity is widely distributed in environmental fields and biological matrices.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Uniformly Sized Molecularly Imprinted Polymers for Phenolic Compounds and Their Application to the Assay of Bisphenol A in River Water

2003

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Uniformly sized molecularly imprinted polymers, which can recognize bisphenol A (BPA), have been prepared by a multi-step swelling and polymerization method using BPA or a structurally related analogue of BPA [p-t-octylphenol (OP) or p-t-butylphenol (BP)] as the template molecule, 4-vinylpyridine as the functional monomer, and ethylene glycol dimethacrylate as the cross-linker. The BP-imprinted polymer showed higher molecular recognition ability for BPA than the OP-imprinted polymer. The BPA-and BP-imprinted polymers were applied for the assay of a trace amount of BPA in river water using column-switching HPLC with fluorescence detection: A BPA-imprinted polymer was used for removal of BPA from the pretreatment eluent as the trap column, and a BP-imprinted polymer was used for selective pretreatment and enrichment of BPA in river water as the pretreatment column. The calibration graph, constructed from peak area data plotted versus BPA concentration, was linear with a correlation coefficient of >0.999 in the concentration ranges of 25 -1000 ppt. The limit of quantitation was 25 ppt with a 5-ml injection. The column-switching HPLC system was successfully applied for the assay of BPA in river water.

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“…O RAM-MIP foi empregado com sucesso na análise direta de (S)-naproxeno em amostras de soro [130] . Ainda nesta linha, o grupo sintetizou também um RAM-MIP empregando (S)-naproxeno ou ibuprofeno como molécula modelo, e os polí-meros obtidos foram utilizados na análise direta de amostras de soro através do sistema column--switching [131] . A metodologia foi empregada na obtenção de RAM-MIPs para análise de anti--inflamatórios não esteroidais, [132] antiepiléti-cos [133] e bisfenol-A [134] em amostras de água de rio.…”

Section: Extração Por Polímeros De Impressão Molecular Restritos à LIunclassified

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Santos¹,

Abrão²,

Freitas³

et al. 2012

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ResumoOs polímeros de impressão molecular são materiais sintéticos dotados de sítios específicos de reconhecimento. Esses materiais são obtidos por reações de polimerização que fixam, estrategicamente, monômeros funcionais ao redor de uma molécula modelo de acordo com os grupos ligantes e com a estereoquímica de ambas as moléculas. Os MIPs têm sido amplamente empregados em procedimentos de preparo de amostras, como extração e microextração em fase sólida, extração sortiva em barra de agitação, extração com adsorvente magnético, microextração com sorvente empacotado, entre outras. Este artigo de revisão tem como objetivo apresentar o que há de mais recente no emprego de MIP para extração de compostos orgânicos, evidenciando as vantagens de cada aplicação, bem como as mais promissoras tendências que sustentam a evolução e o aperfeiçoamento de cada técnica. Palavras-chavePolímeros de impressão molecular; MIP; preparo de amostras.Molecularly imprinted polymers in sample preparation for organic compounds analysis: applications and trends AbstractMolecularly imprinted polymers are synthetic materials with molecular recognition ability. These materials are obtained by polymerization reactions that fix the functional monomers around the template molecule according with the binding groups and the stereochemistry of both molecules. The MIPs have been extensively used in several applications with emphasis for sample preparation procedures as solid phase extraction, solid phase microextraction, extraction by magnetic sorbents, microextraction by packed sorbent among others. So, the objective of this review is to present the novelty in MIP use for organic compounds extraction and point out the advantages of each application, as well as what is most promising in the evolution and improvement of each technique.

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Uniform-Sized Molecularly Imprinted Polymers for 2-Arylpropionic Acid Derivatives Selectively Modified with Hydrophilic External Layer and Their Applications to Direct Serum Injection Analysis

Cited by 154 publications

References 20 publications

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Preparation of Uniformly Sized Molecularly Imprinted Polymers for Phenolic Compounds and Their Application to the Assay of Bisphenol A in River Water

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

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