Uniform size PEGylated iron oxide nanoparticles as a potential theranostic agent synthesized by a simple optimized coprecipitation route

Arsalani, Soudabeh; Hadadian, Yaser; Mazon, E E; Guidelli, Éder José; Kava, Emanuel; Ramos, Ana Paula; Gualdi, A. J.; Pavan, Theo Z.; Baffa, Oswaldo; Carneiro, Antônio Adilton Oliveira

doi:10.1016/j.jmmm.2022.170091

Cited by 11 publications

(8 citation statements)

References 66 publications

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“…In drug delivery systems, nanomaterials are often coated with organic functionalities to enrich additional characteristics. In the past few years, Polyethylene glycol amine (PEG-NH2) is widely used for surface modification of nanomaterials, as it conveys hydrophilicity, provides stability against agglomeration, improves biocompatibility, decreases toxicity, reduces aggregation, and offers rapid absorption by the reticuloendothelial system with prolonged circulation time 38 – 43 . In this study we developed BMS202-functionalized nanocomplexes that had higher zeta potentials than the bare ND.…”

Section: Discussionmentioning

confidence: 99%

“…The rationale for the current study is based on several reports examining the potential for using nanotechnology to both improve drug delivery and enhance immune checkpoint responses in cancer models including melanoma 26 , 27 , 33 – 37 . Nanodiamonds are considered to be a useful nanomaterial for the development of such drug delivery platforms on the basis of their stability, clearance and non-toxicity 38 – 43 . A proof-of-concept drug delivery system was developed based on nanodiamonds loaded with a small molecule inhibitor of PD-1/PD-L1 immune checkpoint inhibitor (ICI) (BMS202) 23 , 29 , 44 (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition

Alharbi,

Qanash,

Binsaleh

et al. 2023

Sci Rep

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Immunotherapies, including immune checkpoint inhibitors, have limitations in their effective treatment of malignancies. The immunosuppressive environment associated with the tumor microenvironment may prevent the achievement of optimal outcomes for immune checkpoint inhibitors alone, and nanotechnology-based platforms for delivery of immunotherapeutic agents are increasingly being investigated for their potential to improve the efficacy of immune checkpoint blockade therapy. In this manuscript, nanoparticles were designed with appropriate size and surface characteristics to enhance their retention of payload so that they can transmit their loaded drugs to the tumor. We aimed to enhance immune cell stimulation by a small molecule inhibitor of PD-1/PD-L1 (BMS202) using nanodiamonds (ND). Melanoma cells with different disease stages were exposed to bare NDs, BMS202-NDs or BMS202 alone for 6 h. Following this, melanoma cells were co-cultured with freshly isolated human peripheral blood mononuclear cells (hPBMCs). The effects of this treatment combination on melanoma cells were examined on several biological parameters including cell viability, cell membrane damage, lysosomal mass/pH changes and expression of γHA2X, and caspase 3. Exposing melanoma cells to BMS202-NDs led to a stronger than normal interaction between the hPBMCs and the melanoma cells, with significant anti-proliferative effects. We therefore conclude that melanoma therapy has the potential to be enhanced by non-classical T-cell Immune responses via immune checkpoint inhibitors delivered by nanodiamonds-based nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition

Alharbi,

Qanash,

Binsaleh

et al. 2023

Sci Rep

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“…A magnetic separation system was used to measure the separation time of the aforementioned NPs, which highly depends on particle size distribution [ 10 , 36 ]. In this study, we used a magnetic separation system to examine the interaction between Ci-MnFe 2 O 4 and CTAB-GNRs by measuring the separation time of Ci-MnFe 2 O 4 and Ci-MnFe 2 O 4 _CTAB-GNRs samples separately.…”

Section: Methodsmentioning

confidence: 99%

“…The next step was to assemble the background of the phantoms with a cylindrical mold (7 cm in diameter and 2.5 cm in height). This part of phantom was made using the same procedures as previously described for inclusion preparation [ 10 ], but with a single modification of mixing 6 wt% gelatin with 3 wt% agar (HIMEDIA supplied Bacteriologic CAT. RM026, Thane, India).…”

Section: Methodsmentioning

confidence: 99%

“…In addition, magnetic nanoparticles (MNPs) have been extensively used in a variety of applications such as biology and biomedicine, owing to their unique features [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Manganese ferrites (MnFe 2 O 4 ) are interesting spinel ferrite NPs among the various mixed ferrites (Afe 2 O 4 ) with other transition metal ions (e.g., A = Mn, Ni, Cu, and Zn) due to their biocompatibility, saturation magnetization, and chemical stability [ 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Hybrid Nanoparticles of Citrate-Coated Manganese Ferrite and Gold Nanorods in Magneto-Optical Imaging and Thermal Therapy

et al. 2023

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The development of nanomaterials has drawn considerable attention in nanomedicine to advance cancer diagnosis and treatment over the last decades. Gold nanorods (GNRs) and magnetic nanoparticles (MNPs) have been known as commonly used nanostructures in biomedical applications due to their attractive optical properties and superparamagnetic (SP) behaviors, respectively. In this study, we proposed a simple combination of plasmonic and SP properties into hybrid NPs of citrate-coated manganese ferrite (Ci-MnFe2O4) and cetyltrimethylammonium-bromide-coated GNRs (CTAB-GNRs). In this regard, two different samples were prepared: the first was composed of Ci-MnFe2O4 (0.4 wt%), and the second contained hybrid NPs of Ci-MnFe2O4 (0.4 wt%) and CTAB-GNRs (0.04 wt%). Characterization measurements such as UV-Visible spectroscopy and transmission electron microscopy (TEM) revealed electrostatic interactions caused by the opposing surface charges of hybrid NPs, which resulted in the formation of small nanoclusters. The performance of the two samples was investigated using magneto-motive ultrasound imaging (MMUS). The sample containing Ci-MnFe2O4_CTAB-GNRs demonstrated a displacement nearly two-fold greater than just using Ci-MnFe2O4; therefore, enhancing MMUS image contrast. Furthermore, the preliminary potential of these hybrid NPs was also examined in magnetic hyperthermia (MH) and photoacoustic imaging (PAI) modalities. Lastly, these hybrid NPs demonstrated high stability and an absence of aggregation in water and PBS medium. Thus, Ci-MnFe2O4_CTAB-GNRs hybrid NPs can be considered as a potential contrast agent in MMUS and PAI and a heat generator in MH.

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Preparation of Dextran- and Carboxymethyl Dextran–Coated Fe3O4 Nanoparticles for Breast Cancer Cell Labeling and Magnetic Hyperthermia

Ying,

Zhou,

et al. 2024

J Supercond Nov Magn

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Uniform size PEGylated iron oxide nanoparticles as a potential theranostic agent synthesized by a simple optimized coprecipitation route

Cited by 11 publications

References 66 publications

Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition

Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition

Hybrid Nanoparticles of Citrate-Coated Manganese Ferrite and Gold Nanorods in Magneto-Optical Imaging and Thermal Therapy

Preparation of Dextran- and Carboxymethyl Dextran–Coated Fe3O4 Nanoparticles for Breast Cancer Cell Labeling and Magnetic Hyperthermia

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