This paper studies Frobenius powers of parameter ideals in a commutative Noetherian local ring R of prime characteristic p. For a given ideal a of R, there is a power Q of p, depending on a, such that the Qth Frobenius power of the Frobenius closure of a is equal to the Qth Frobenius power of a. The paper addresses the question as to whether there exists a uniform Q 0 which 'works' in this context for all parameter ideals of R simultaneously.In a recent paper, Katzman and Sharp proved that there does exists such a uniform Q 0 when R is CohenMacaulay. The purpose of this paper is to show that such a uniform Q 0 exists when R is a generalized Cohen-Macaulay local ring. A variety of concepts and techniques from commutative algebra are used, including unconditioned strong d-sequences, cohomological annihilators, modules of generalized fractions, and the Hartshorne-Speiser-Lyubeznik Theorem employed by Katzman and Sharp in the Cohen-Macaulay case. (C. Huneke), m.katzman@sheffield.ac.uk (M. Katzman), r.y.sharp@sheffield.ac.uk (R.Y. Sharp), ywyao@umich.edu (Y. Yao).