Uniform and improved bioavailability of newly developed rapid and sustained release suspensions of ibuprofen microspheres

Kawashima, Yasunaru; Iwamoto, Taro; Niwa, Toshiyuki; Takeuchi, Hirofumi; Hino, Tomoaki

doi:10.1016/0378-5173(93)90302-v

Cited by 14 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These systems have several advantages, such as (Kawashima et al, 1993;Lin and Kao, 1991;Murilo et al, 2002) ready distribution over a large surface area, more constant drug plasma levels, higher accuracy in reproducibility dose by dose, no negative impact on bioavailability, lower risk of toxicity due to dose dumping, gastrointestinal tract protection from drug toxicity, labile drug protection from degradation in the gastrointestinal tract and antigen delivery to the Peyer's patches for oral immunization.…”

Section: Introductionmentioning

confidence: 99%

“…Polymeric microparticles are widely studied in the pharmaceutical field for the purpose, among others, of obtaining better results in the oral administration of drugs by the production of multiple-unit drug delivery systems (Kawashima et al, 1993;Lin and Kao, 1991). These systems have several advantages, such as (Kawashima et al, 1993;Lin and Kao, 1991;Murilo et al, 2002) ready distribution over a large surface area, more constant drug plasma levels, higher accuracy in reproducibility dose by dose, no negative impact on bioavailability, lower risk of toxicity due to dose dumping, gastrointestinal tract protection from drug toxicity, labile drug protection from degradation in the gastrointestinal tract and antigen delivery to the Peyer's patches for oral immunization.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Beck

Lionzo

Costa

et al. 2008

Braz. J. Chem. Eng.

View full text Add to dashboard Cite

-This paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SEM analyses showed nanostructures coating the surface of nanocapsule-coated microparticles and a rugged surface for nanosphere-coated microparticles. The decrease in their surface areas was controlled by the nanoparticulated system, which was not dependent on microparticle size. Optical microscopy and X-ray analyses indicated that acid diclofenac crystals were present in formulations prepared with the acid as well as in the nanocapsule-coated microparticles prepared with the salt. The control of coating is dependent on the use of nanocapsules or nanospheres and independent of either the characteristics of the drug or the method of preparing the core.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Beck

Lionzo

Costa

et al. 2008

Braz. J. Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…The ethanol diffusions from emulsion droplets into the aqueous media were monitored by measuring the concentrations of ethanol in water phase with gas chromatography (Kawashima et al 1992). Figure 2 shows a typical diffusion profile.…”

Section: Difjusion Rate Of Ethanol From Emulsion Droplets Into Water mentioning

confidence: 99%

“…Furthermore, the advantages of this method included simple and faster processing, and avoidance of harmful organic solvents and additives, which remained in the final products. By applying these microspheres a new controlled-release suspension was developed (Kawashima et al 1991(Kawashima et al , 1992.…”

Section: Introductionmentioning

confidence: 99%

Role of the solvent-diffusion-rate modifier in a new emulsion solvent diffusion method for preparation of ketoprofen microspheres

Kawashima

Iwamoto

Niwa

et al. 1993

Journal of Microencapsulation

View full text Add to dashboard Cite

A new emulsion solvent diffusion method to prepare the microspheres of ketoprofen with an acrylic polymer was developed by utilizing sugar esters as solvent diffusion modifiers. The microspheres were produced via transient o/w emulsion droplets of the polymer, which was formed by the interaction of drug and water-miscible organic solvent, e.g. ethanol. The solvent consisting in oil droplets diffused into the outer aqueous medium. In the droplets, ethanol interacted with ketoprofen via hydrogen bonding between -OH group of ethanol and both -COOH and = CO groups of ketoprofen. These hydrogen bonds made ethanol solution strongly hydrophobic. The sugar ester added in the ethanol could inhibit such intermolecular interaction between ethanol and the = CO group of ketoprofen. Modulation in the binding force of ketoprofen-ethanol by the sugar ester contributed to achieving a desirable initial ethanol diffusion rate from the oil droplets for the formation of ketoprofen microspheres with high yield (> 85 per cent) and drug entrapment ratio (> 90 per cent).

show abstract

“…Microparticles are generally composed by polymeric materials and present advantages such as a rapid and one step production, ready distribution on a large surface of the body, more constant plasma levels, higher accuracy in reproducibility dose-by dose, less decrease in bioavailability and minor risk of toxicity due to the dose dumping [12,13]. A modern microparticle formulation should be able to provide a controlled and well-defined drug release pattern.…”

Section: Introductionmentioning

confidence: 99%

Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview

2009

View full text Add to dashboard Cite

Polymeric nanoparticle systems (nanocapsules and nanospheres) present potential applications as drug delivery systems. Nevertheless, their full applications have not been exploited due to their limited shelf life when stored in aqueous medium. Drying polymeric nanoparticles using spray-drying represents a promising platform to improve the physicochemical stability of formulations and/or to control the release of hydrophilic and lipophilic drugs. This article presents a brief overview of the most recent and ongoing research in the use of spray-drying process to prepare and/or to dry polymeric nanoparticles formulations intended for drug administration.

show abstract

Uniform and improved bioavailability of newly developed rapid and sustained release suspensions of ibuprofen microspheres

Cited by 14 publications

References 19 publications

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Role of the solvent-diffusion-rate modifier in a new emulsion solvent diffusion method for preparation of ketoprofen microspheres

Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview

Contact Info

Product

Resources

About