Unifocal Langerhans Cell Histiocytosis of the Superior Oblique Muscle

Narayan, Daniel S.; Figueira, Edwin C.; Kearney, Daniel; McKelvie, Penelope; Davis, Garry; Selva, Dinesh

doi:10.1097/iop.0000000000000072

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Literature review in PubMed yielded 68 results using the terms “langerhans cell histiocytosis and orbit” of which there are 15 applicable results outlined below. There were no complications with treatment 1,9–22 …”

Section: Discussionmentioning

confidence: 98%

“…There were no complications with treatment. 1 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 Abbreviations: FNA, fine needle aspiration; ILS, intralesional steroids; IVCT, IV chemotherapy (etoposide, cisplatin), steroids (methylprednisolone or prednisolone); OCT, oral chemotherapy (6 mercaptopurine, vincristine, vinblastine). …”

Section: Discussionmentioning

confidence: 99%

“…There were no complications with treatment. 1 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Successful treatment of orbital Langerhans cell histiocytosis with stereotactic radiosurgery: A case report and literature review

Etter

Bosse

Wang

et al. 2023

Clinical Case Reports

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Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm arising from the proliferation of pathologic Langerhans cells. LCH has a spectrum of presentations predominantly affecting male pediatric patients. As LCH is a relatively uncommon diagnosis, there is no standard of care for treatment of the disease and treatment is based largely on clinical judgment, lesion characteristics, and symptoms at presentation. Here we present a case of unifocal, isolated orbital LCH in a 19-year-old young man treated initially with surgical resection. Follow-up imaging 2 months later demonstrated significant regrowth of the mass and no other sites of disease. The recurrent orbital disease was treated with stereotactic radiosurgery (SRS) to 7 Gy in one fraction. Near complete resolution of the mass was achieved with no recurrence after 1.5 years of follow-up. SRS for treatment of orbital LCH is a novel treatment not previously described in the literature which may provide benefit in select cases.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Successful treatment of orbital Langerhans cell histiocytosis with stereotactic radiosurgery: A case report and literature review

Etter

Bosse

Wang

et al. 2023

Clinical Case Reports

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show abstract

“…3). [43][44][45][46][47][48][49] Treatments including tumor excision, debulking, radiotherapy, and chemotherapy have been used successfully.…”

Section: Discussionmentioning

confidence: 99%

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

Plemel¹,

Benson²,

Tong³

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: Langerhans cell histiocytosis (LCH) is a disorder of dendritic cell proliferation that typically involves bone. It can be diagnostically challenging when LCH presents without bony involvement, leading to delays in diagnosis and treatment. In this study, the periocular manifestations of LCH in cases where the underlying orbital bones are not involved are described through a systematic review. Methods: A systematic review of the literature was performed to capture all cases of LCH that involved the periocular region but not the underlying orbital bones. These included LCH cases that involved the periocular skin, the ocular surface, and the orbital tissue. The authors also highlight an additional case where LCH presented with periocular edema and multifocal, nodular conjunctival lesions. Result: This review illustrates that LCH rarely presents with periocular infiltration without orbital bone involvement. In these atypical cases, LCH can present as an eyelid mass, a chalazion-like lesion, generalized periocular swelling, ocular surface lesions, or infiltration of any orbital structure. Ocular surface LCH has a higher rate of recurrence than other periocular LCH. Orbital LCH can involve any tissue including extraocular muscles, the lacrimal gland, or indistinct areas within the orbit. Conclusions: LCH is a clinicopathologic diagnosis. Although most cases involve the bone, any soft tissue can be involved. Biopsy is required to confirm the diagnosis of this heterogeneous disease.

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Unifocal Langerhans Cell Histiocytosis of the Superior Oblique Muscle

Cited by 2 publications

References 14 publications

Successful treatment of orbital Langerhans cell histiocytosis with stereotactic radiosurgery: A case report and literature review

Successful treatment of orbital Langerhans cell histiocytosis with stereotactic radiosurgery: A case report and literature review

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

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