Unifocal Langerhans' Cell Histiocytosis (Eosinophilic Granuloma) of the Petrous Apex

Goldsmith, Ari J.; Myssiorek, David; Valderrama, Elsa; Patel, Mahendra

doi:10.1001/archotol.1993.01880130115018

Cited by 39 publications

(20 citation statements)

References 17 publications

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“…2,4,8,20) Sensorineural hearing losses in previous cases have been chronic, 21) fluctuating, 5) or progressive, 8) whereas the present case showed sudden onset of hearing loss. Extension of the lesion to the skull base may cause palsy of other cranial nerves such as the abducens, [2][3][4]8,11,13) trigeminal, 4) optic, 11) and vagus 2) nerves. The present patient suffered sudden sensorineural hearing loss and vertigo without other cranial nerve palsy or neurological deficits, mimicking idiopathic sudden sensorineural hearing loss.…”

Section: Discussioncontrasting

confidence: 42%

“…Anonsen et al reported that only 4 of 24 LCH cases of the head and neck involved the mastoid, and only one case involved the petrous bone. 1) Patients with petrous bone involvement may present with sensorineural hearing loss, 2,5,8) vertigo, 2,5,21) and facial nerve palsy. 2,4,8,20) Sensorineural hearing losses in previous cases have been chronic, 21) fluctuating, 5) or progressive, 8) whereas the present case showed sudden onset of hearing loss.…”

Section: Discussionmentioning

confidence: 99%

“…1) Patients with petrous bone involvement may present with sensorineural hearing loss, 2,5,8) vertigo, 2,5,21) and facial nerve palsy. 2,4,8,20) Sensorineural hearing losses in previous cases have been chronic, 21) fluctuating, 5) or progressive, 8) whereas the present case showed sudden onset of hearing loss. Extension of the lesion to the skull base may cause palsy of other cranial nerves such as the abducens, [2][3][4]8,11,13) trigeminal, 4) optic, 11) and vagus 2) nerves.…”

Section: Discussionmentioning

confidence: 99%

“…10) However, petrous bone lesions are not readily accessible, and most reported cases underwent only diagnostic biopsy or curettage. 3,8,13,[19][20][21] Low-dose radiotherapy is effective for LCH, and is generally used at a dose of 5-25 Gy. 10,13) Chemotherapy is indicated for multifocal or multisystem LCH.…”

Section: Discussionmentioning

confidence: 99%

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Langerhans Cell Histiocytosis of the Petrous Bone With Sudden Sensorineural Hearing Loss -Case Report-

Suzuki

Nishizawa

Hohchi

et al. 2010

Neurol. Med. Chir.(Tokyo)

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A 56-year-old woman with Langerhans cell histiocytosis of the petrous bone presented with sudden onset of sensorineural hearing loss and vertigo without other neurological impairment, mimicking idiopathic sudden sensorineural hearing loss. Differential diagnosis was difficult until neuroimaging demonstrated a lesion of the petrous bone. The patient eventually underwent removal of the lesion via the transpetrosal approach, and received postoperative chemotherapy consisting of vinblastine, methotrexate, 6-mercaptopurine, and prednisolone. Although her hearing did not recover, complete remission was achieved, and the patient is currently free from disease. Physicians need to be aware that patients with sudden onset of hearing loss may have an unexpected and hidden disease which requires neuroimaging and histological examinations for definitive diagnosis and appropriate treatment.

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Section: Discussioncontrasting

confidence: 42%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Langerhans Cell Histiocytosis of the Petrous Bone With Sudden Sensorineural Hearing Loss -Case Report-

Suzuki

Nishizawa

Hohchi

et al. 2010

Neurol. Med. Chir.(Tokyo)

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“…Langerhans cell histiocytosis (LCH), formerly known as histiocytosis X, includes a spectrum of diseases characterized by proliferation of histiocytes in different tissues, producing local or systemic effects [1,2] . The term includes eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease.…”

Section: Introductionmentioning

confidence: 99%

Petrous Bone Langerhans Cell Histiocytosis Treated with Radiosurgery

Rı́o

Lassaletta

Martínez

et al. 2007

Stereotact Funct Neurosurg

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Langerhans cell histiocytosis (LCH) is a rare disease that may show as a solitary or multifocal lesion of bone, soft tissue or viscera. Involvement of the temporal bone has been described in 15–61% of patients with LCH, usually in association with multisystemic involvement. We report the case of a 30-year-old man presenting with vertigo and fluctuating hearing loss caused by monosystemic LCH of the left petrous bone. The patient was treated with radiosurgery (covering dose 10 Gy at 85% isodose, maximum dose 11.76 Gy). Two years after treatment, no evidence of recurrent disease was found in the CT scan or MRI. We discuss the treatment of temporal bone LCH, traditionally based on surgery, low-dose radiation therapy and intralesional steroids. To our knowledge, this is the first reported case of LCH of the petrous bone successfully treated with radiosurgery. This approach may be interesting in cases of LCH located on nonaccessible areas of the temporal bone.

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Langerhans' cell histiocytosis: Head and neck manifestations in children

Quraishi¹,

Blayney

Walker³

et al. 1995

Head & Neck

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Atypical cellular disorders are commonly considered part of the gray zone linking oncology to hematology and immunology. Although these disorders are relatively uncommon, they often represent significant clinical problems, provide an opportunity to understand basic disease mechanisms , and serve as model systems for the development of novel targeted therapies. This chapter focuses on such disorders. In Section I, Dr. Arceci discusses the pathogen-esis of Langerhans cell histiocytosis (LCH) in terms of the hypothesis that this disorder represents an atypical myeloproliferative syndrome. The clinical manifestations and treatment of LCH in children and adults is discussed along with possible future therapeutic approaches based upon biological considerations. In Section II, Dr. Longley considers the molecular changes in the c-Kit receptor that form the basis of mastocytosis. Based on the location and function of c-Kit mutations, he develops a paradigm for the development of specific, targeted therapies. In Section III, Dr. Emanuel provides a review of the "mixed myeloproliferative and myelodysplastic disorders," including novel therapeutic approaches based on aberrant pathogenetic mechanisms. Taken together, these chapters should provide an overview of the biological basis for these disorders, their clinical manifestations, and new therapeutic approaches

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Unifocal Langerhans' Cell Histiocytosis (Eosinophilic Granuloma) of the Petrous Apex

Cited by 39 publications

References 17 publications

Langerhans Cell Histiocytosis of the Petrous Bone With Sudden Sensorineural Hearing Loss -Case Report-

Langerhans Cell Histiocytosis of the Petrous Bone With Sudden Sensorineural Hearing Loss -Case Report-

Petrous Bone Langerhans Cell Histiocytosis Treated with Radiosurgery

Langerhans' cell histiocytosis: Head and neck manifestations in children

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