Unified validation of a refined second-generation HR-pQCT based homogenized finite element method to predict strength of the distal segments in radius and tibia

Schenk, Denis; Indermaur, Michael; Simon, Mathieu; Voumard, Benjamin; Варга, П.; Pretterklieber, Michael L.; Lippuner, Kurt; Zysset, Philippe

doi:10.1016/j.jmbbm.2022.105235

Cited by 3 publications

(9 citation statements)

References 37 publications

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“…This study used the tibiae sample presented in Schenk et al (2022) . Briefly, 25 fresh frozen anatomic samples of human tibiae were obtained from the Division of Anatomy of the Medical University of Vienna, Austria, with the authorisation of the local ethics committee.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally to Schenk et al (2022) , μCT scans (microCT 100, Scanco Medical AG, Switzerland) were performed before and after mechanical testing in saline solution with an isotropic 24.5 μm voxel size. Scan parameters were for energy: 70 kVp, current: 200 μA and integration time: 300 ms.…”

Section: Methodsmentioning

confidence: 99%

“…These scans were then downscaled to a voxel size of 72.5 μm (factor 3) to approximately match the HR-pQCT resolution. These μCT scans allow to first, compare results with clinical HR-pQCT-based hFE, using results of Schenk et al (2022) , and second, to compute the deformation field resulting from the compression experiment.…”

Section: Methodsmentioning

confidence: 99%

“…Then, the cortical mask, the trabecular mask and the 3 labels segmented image (no bone, trabecular bone, and cortical bone) were generated using a threshold-based algorithm (cortical bone: 450 mgHA/cm 3 , trabecular bone: 320 mgHA/cm 3 ) ( Whittier et al, 2020 ) with Gauss filtering (sigma = 0.8, support = 1 voxel). Morphometric analysis was performed using the manufacturer's software on pre and post-test downscaled μCT images as well as on the HR-pQCT scans from Schenk et al (2022) . The resulting parameters, bone volume fraction (BV/TV), trabecular thickness (Tb.…”

Section: Methodsmentioning

confidence: 99%

“…HR-pQCT together with hFE analysis allows excellent prediction of bone stiffness and strength of the distal segment of the radius ( Dünki et al, 2014 ; Hosseini et al, 2017 ). Moreover, a more recent study has shown that the same properties can be used to predict stiffness and strength of both the distal segment of the radius and the tibia ( Schenk et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Homogenized finite element analysis of distal tibia sections: Achievements and limitations

Simon,

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Bone Reports

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Homogenized finite element analysis of distal tibia sections: Achievements and limitations

Simon,

Indermaur,

Schenk

et al. 2024

Bone Reports

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Comparison of Motion Grading in 1,000 Patients by First- and Second-Generation HR-pQCT: A Propensity Score Matched Cohort Study

Bartosik,

Simon,

Strahl

et al. 2023

Calcif Tissue Int

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In-vivo bone microstructure measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) is gaining importance in research and clinical practice. Second-generation HR-pQCT (XCT2) shows improved image quality and shorter measurement duration compared to the first generation (XCT1). Predicting and understanding the occurrence of motion artifacts is crucial for clinical practice. We retrospectively analyzed data from HR-pQCT measurements at the distal radius and tibia of 1,000 patients (aged 20 to 89) evenly distributed between both generations of HR-pQCT. Motion artifacts were graded between 1 (no motion) and 5 (severe motion), with grades greater 3 considered unusable. Additionally, baseline characteristics and patients’ muscle performance and balance were measured. Various group comparisons between the two generations of HR-pQCT and regression analyses between patient characteristics and motion grading were performed. The study groups of XCT1 and XCT2 did not differ by age (XCT1: 64.9 vs. XCT2: 63.8 years, p = 0.136), sex (both 74.5% females, p > 0.999), or BMI (both 24.2 kg/m2, p = 0.911) after propensity score matching. XCT2 scans exhibited significantly lower motion grading in both extremities compared to XCT1 (Radius: p < 0.001; Tibia: p = 0.002). In XCT2 motion-corrupted scans were more than halved at the radius (XCT1: 35.3% vs. XCT2: 15.5%, p < 0.001), and at the tibia the frequency of best image quality scans was increased (XCT1: 50.2% vs. XCT2: 63.7%, p < 0.001). The strongest independent predictor for motion-corrupted images is the occurrence of high motion grading at the other scanning site during the same consultation. The association between high motion grading in one scan and a corresponding high motion grading in another scan within the same session suggests a non-resting patient. Additionally, aged, female, and patients with smaller stature tend towards higher motion grading, requiring special attention to a correct extremity fixation.

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Hydrogel-chitosan and polylactic acid-polycaprolactone bioengineered scaffolds for reconstruction of mandibular defects: a preclinical in vivo study with assessment of translationally relevant aspects

Ferrari,

Taboni,

Chan

et al. 2024

Front. Bioeng. Biotechnol.

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Background: Reconstruction of mandibular bone defects is a surgical challenge, and microvascular reconstruction is the current gold standard. The field of tissue bioengineering has been providing an increasing number of alternative strategies for bone reconstruction.Methods: In this preclinical study, the performance of two bioengineered scaffolds, a hydrogel made of polyethylene glycol-chitosan (HyCh) and a hybrid core-shell combination of poly (L-lactic acid)/poly (ε-caprolactone) and HyCh (PLA-PCL-HyCh), seeded with different concentrations of human mesenchymal stromal cells (hMSCs), has been explored in non-critical size mandibular defects in a rabbit model. The bone regenerative properties of the bioengineered scaffolds were analyzed by in vivo radiological examinations and ex vivo radiological, histomorphological, and immunohistochemical analyses.Results: The relative density increase (RDI) was significantly more pronounced in defects where a scaffold was placed, particularly if seeded with hMSCs. The immunohistochemical profile showed significantly higher expression of both VEGF-A and osteopontin in defects reconstructed with scaffolds. Native microarchitectural characteristics were not demonstrated in any experimental group.Conclusion: Herein, we demonstrate that bone regeneration can be boosted by scaffold- and seeded scaffold-reconstruction, achieving, respectively, 50% and 70% restoration of presurgical bone density in 120 days, compared to 40% restoration seen in spontaneous regeneration. Although optimization of the regenerative performance is needed, these results will help to establish a baseline reference for future experiments.

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Unified validation of a refined second-generation HR-pQCT based homogenized finite element method to predict strength of the distal segments in radius and tibia

Cited by 3 publications

References 37 publications

Homogenized finite element analysis of distal tibia sections: Achievements and limitations

Homogenized finite element analysis of distal tibia sections: Achievements and limitations

Comparison of Motion Grading in 1,000 Patients by First- and Second-Generation HR-pQCT: A Propensity Score Matched Cohort Study

Hydrogel-chitosan and polylactic acid-polycaprolactone bioengineered scaffolds for reconstruction of mandibular defects: a preclinical in vivo study with assessment of translationally relevant aspects

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