Unhealthy lifestyle in early psychoses: The role of life stress and the hypothalamic–pituitary–adrenal axis

Manzanares, Nuria García; Monseny, Rosa; Ortega, Laura; Montalvo, Itziar; Franch, J.; Gutiérrez-Zotes, Alfonso; Reynolds, Rebecca M.; Walker, Brian R.; Vilella, Elisabet; Labad, Javier

doi:10.1016/j.psyneuen.2013.09.023

Cited by 40 publications

(33 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Food craving refers to an intense desire or urge to eat specific foods of which chocolate is the most often craved one among other highly palatable foods. 33 In line with our previous study, 6 ARMS individuals that are Met-allele carriers of the BDNF Val66Met polymorphism also report lower craving for foods (with similar FCQ-S scores as HS), when compared to PD patients that are Met-allele carriers. The mechanistic pathways leading to a distinct relationship between perceived stress, calorie intake and BDNF genotype in ARMS and PD groups are uncertain.…”

Section: Discussionsupporting

confidence: 82%

“…4,5 Life stress is associated with greater calorie intake and increased refined sugar consumption in individuals with early psychosis. 6 This is in accordance with other studies in non-psychiatric populations, which have also found that chronic stress is associated with hyperphagia. 7,8 Psychosocial stress is implicated in the development of psychotic symptoms.…”

Section: Introductionsupporting

confidence: 92%

See 1 more Smart Citation

Gene‐environment interaction between the brain‐derived neurotrophic factor Val66Met polymorphism, psychosocial stress and dietary intake in early psychosis

Gattere

Stojanovic-Pérez

Monseny

et al. 2016

Early Intervention Psych

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Introductionsupporting

confidence: 92%

Gene‐environment interaction between the brain‐derived neurotrophic factor Val66Met polymorphism, psychosocial stress and dietary intake in early psychosis

Gattere

Stojanovic-Pérez

Monseny

et al. 2016

Early Intervention Psych

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent meta‐analysis of 31 studies about dietary patterns identified a high consumption of saturated fat and low intake of fruit and dietary fiber . The unhealthy dietary pattern has also been identified in subjects at high risk for psychosis who had higher intake of saturated fat and calories than healthy control subjects . A detailed, controlled investigation indicated that patients with schizophrenia had higher daily intake of calories and protein per kilogram of body weight, which was independent of BMI .…”

Section: Resultsmentioning

confidence: 99%

Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management

Manu

Dima

Shulman

et al. 2015

Acta Psychiatr Scand

227

125

View full text Add to dashboard Cite

show abstract

“…It is important to study early phase psychosis in order to treat patients as early as possible, and recent research has shown that individuals with early phase psychosis can provide information for intervention prior to development of full blown psychosis (Manzanares et al, 2014). The current study compared MMN data between early phase psychosis patients and healthy controls while using the complex pattern MMN paradigm.…”

Section: Introductionmentioning

confidence: 99%

Finding the missing-stimulus mismatch negativity (MMN) in early psychosis: Altered MMN to violations of an auditory gestalt

Rudolph

Ells

Campbell

et al. 2015

Schizophrenia Research

View full text Add to dashboard Cite

The mismatch negativity (MMN) is an EEG-derived event-related potential (ERP) elicited by any violation of a predicted auditory ‘rule’, regardless of whether one is attending to the stimuli, and is thought to reflect updating of the stimulus context. Chronic schizophrenia patients exhibit robust MMN deficits, while MMN reduction in first-episode and early phase psychosis is significantly less consistent. Traditional two-tone “oddball” MMN measures of sensory information processing may be considered too simple for use in early phase psychosis in which pathology has not progressed fully, and a paradigm that probes higher order processes may be more appropriate for elucidating auditory change detection deficits. This study investigated whether MMN deficits could be detected in early phase psychosis (EP) patients using an abstract ‘missing stimulus’ pattern paradigm (Salisbury, 2012). The stimuli were 400 groups of six tones (1000 Hz, 50 ms duration, 330 ms stimulus onset asynchrony), which was presented with an inter-trial interval of 750 ms. Occasionally a group contained a deviant, meaning that it was missing either the 4th or 6th tone (50 trials each). EEG recordings of 13 EP patients (≤5 year duration of illness) and 15 healthy controls (HC) were collected. Patients and controls did not significantly differ on age or years of education. Analyses of MMN amplitudes elicited by missing stimuli revealed amplitude reductions in EP patients, suggesting that these deficits are present very early in the progression of the illness. While there were no correlations between MMN measures and measures such as duration of illness, medication dosage or age, MMN amplitude reductions were correlated with positive symptomatology (i.e. auditory hallucinations). These findings suggest that MMNs elicited by the ‘missing stimulus’ paradigm are impaired in psychosis patients early in the progression of illness and that previously reported MMN-indexed deficits related to auditory hallucinations in chronic patients may also be present in EP patients. As such, this paradigm may have promise in identifying early processing deficits in this population.

show abstract

Unhealthy lifestyle in early psychoses: The role of life stress and the hypothalamic–pituitary–adrenal axis

Cited by 40 publications

References 40 publications

Gene‐environment interaction between the brain‐derived neurotrophic factor Val66Met polymorphism, psychosocial stress and dietary intake in early psychosis

Gene‐environment interaction between the brain‐derived neurotrophic factor Val66Met polymorphism, psychosocial stress and dietary intake in early psychosis

Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management

Finding the missing-stimulus mismatch negativity (MMN) in early psychosis: Altered MMN to violations of an auditory gestalt

Contact Info

Product

Resources

About