Ung jente med psykose, kognitiv svikt og kramper

Slettedal, Imer Önder; Dahl, Hilde Margrete; Sandvig, Inger; Dalmau, Josep; Strømme, Petter

doi:10.4045/tidsskr.12.0092

Cited by 14 publications

(4 citation statements)

References 21 publications

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“…The syndrome predominantly presents in young women with 60% of them having a neoplasm (usually, ovarian teratoma). The clinical course is characterised by five stages 2 - prodromal stage, neuro-behavioural stage, nonresponsive stage, hyperactive stage and gradual recovery stage. Children may present with speech regression and irritability instead of catatonia or psychosis.…”

Section: Introductionmentioning

confidence: 99%

Catatonic Syndrome in Anti-NMDA Receptor Encephalitis

Mythri¹,

Mathew

2016

Indian Journal of Psychological Medicine

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Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a newly recognised autoimmune condition. With its typical clinical pattern, consistent association with the presence of auto antibodies and rapid improvement with immunotherapy, this condition is giving insights into the boundaries between psychiatry and other neurosciences, and is opening avenues for future research. In a young lady who presented with catatonia, we considered anti-NMDA receptor encephalitis, after ruling out other aetiologies. After a positive antibody test we treated her with immunotherapy. She showed gradual improvement in her psychotic and catatonic symptoms. Knowledge regarding the nature and function of NMDA receptors and pathophysiology of this particular encephalitis is important for psychiatric practice. The great opportunity for research in this area due to its association with psychotic disorders is evident but an appeal to temper the enthusiasm by considering the historical lessons learnt from Karl Jaspers’ critique of General Paresis of Insane, is in place. Catatonic syndrome has to be conceptualised broadly and should be recognised with a separate nosological position.

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Section: Introductionmentioning

confidence: 99%

Catatonic Syndrome in Anti-NMDA Receptor Encephalitis

Mythri¹,

Mathew

2016

Indian Journal of Psychological Medicine

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“…For instance, a school-aged girl who continued to have impaired cognitive function 18 months after admission improved 2.5 years after admission and completely recovered (normal cognition) after 4.5 years. 30 …”

Section: Discussionmentioning

confidence: 99%

Anti-N-methyl-d-aspartate receptor encephalitis in a patient with a 7-year history of being diagnosed as schizophrenia: complexities in diagnosis and treatment

Huang¹,

Kang²,

Zhang³

et al. 2015

NDT

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Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a form of autoimmune encephalitis associated with antibodies against the NR1 subunits of NMDARs. Although new-onset acute prominent psychotic syndromes in patients with NMDAR encephalitis have been well documented, there is a lack of case studies on differential diagnosis and treatment of anti-NMDAR encephalitis after a long-term diagnostic history of functional psychotic disorders. The present study reports an unusual case of anti-NMDAR encephalitis. The patient had been diagnosed with schizophrenia 7 years earlier, and was currently hospitalized for acute-onset psychiatric symptoms. The diagnosis became unclear when the initial psychosis was confounded with considerations of other neurotoxicities (such as neuroleptic malignant syndrome). Finally, identification of specific immunoglobulin G NR1 autoantibodies in the cerebrospinal fluid and greater effectiveness of immunotherapy over antipsychotics alone (which has been well documented in anti-NMDAR encephalitis) indicated the diagnosis of anti-NMDAR encephalitis in this case. Based on the available evidence, however, the relationship between the newly diagnosed anti-NMDAR encephalitis and the seemingly clear, long-term history of schizophrenia in the preceding 7 years is uncertain. This case report illustrates that psychiatrists should consider anti-NMDAR encephalitis and order tests for specific immunoglobulin G NR1 autoantibodies in patients presenting with disorientation, disturbance of consciousness, cognitive deficit, dyskinesia, autonomic disturbance, or rapid deterioration, even with a seemingly clear history of a psychiatric disorder and no specific findings on routine neuroimaging, electroencephalography, or cerebrospinal fluid tests in the early stage of the illness.

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“…Tilstanden ble første gang beskrevet i 2007 som et paraneoplastisk fenomen og representerer en form for subaku autoimmun hjernebetennelse som typisk manifesterer seg med nevropsykiatriske symptomer. Det har vaert en økende prevalens, og anti-NMDAreseptorencefali er nå den hyppigste autoimmune encefali en (3,(13)(14)(15). Klinisk ser man ved anti-NMDA-reseptorencefali en viruslignende prodromalfase før symptomer som atferdsendring, vrangforestillinger og psykose blir fremtredende (16).…”

Section: Diskusjonunclassified

A man in his forties with acute confusion

et al. 2022

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Nevrologisk avdeling Nordlandssykehuset Merethe Karlberg er spesialist i nevrologi og overlege. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Diagnostisk klinikk Nordlandssykehuset Hanne Thoresen er spesialist i radiologi og overlege. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Nevrofysiologisk seksjon Nordlandssykehuset Diana Hristova Berg er spesialist i nevrologi og LIS-lege i klinisk nevrofysiologi. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Nevrofysiologisk seksjon Nordlandssykehuset Oana-Gratiela Ciopat er spesialist i nevrofysiologi. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Nevrologisk avdeling Nordlandssykehuset og Universitetet i Tromsø Karl Bjørnar Alstadhaug er spesialist i nevrologi, overlege og professor. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. En mann i 40-årene med aku forvirring | Tidsskrift for Den norske legeforening

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Ung jente med psykose, kognitiv svikt og kramper

Abstract: Psychiatric symptoms combined with neurological disturbances should always arouse suspicion that the cause may be organic. We describe a young patient whose examination revealed a recently described condition for which there are precise diagnostics and in many cases effective treatment.

Cited by 14 publications

References 21 publications

Catatonic Syndrome in Anti-NMDA Receptor Encephalitis

Catatonic Syndrome in Anti-NMDA Receptor Encephalitis

Anti-N-methyl-d-aspartate receptor encephalitis in a patient with a 7-year history of being diagnosed as schizophrenia: complexities in diagnosis and treatment

A man in his forties with acute confusion

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