“…Radiation-induced trismus (RIT), one of the most dreadful side effects of C-CRT, is difficult to predict with a high degree of accuracy and has a terrible impact on the quality of life of those who experience it. [4][5][6] RIT may result in many adverse health consequences, including dysphagia, dysgeusia, ageusia, dental disease, orofacial pain, oral infections, and even osteoradionecrosis and difficulties with intubation. 7,8 Although much remains unknown about the process, it is commonly accepted that radiation-induced inflammation, endothelial damage, hypoxia, and fibrosis are the primary reasons for its onset and development.…”