Unfavorable Blood Rheology is Closely Associated with Arterial Stiffness in Obese Patients

Abstract

on atherosclerosis formation in obesity, it is of interest in the relationship between the rheological/microcirculatory conditions as assessed by the MC-FAN and peripheral/cetral arterial stiffness as assessed by pulsewave velocity (PWV) [8]. Our study was aimed to observe the relationship extent among obese patients. Materials and MethodsA total of 109 Japanese obese patients (body mass index (BMI) ≥ 25, 45 men and 64 women, mean age 51.3 years) were enrolled, and consisted of 88 hypertensive patients, 49 diabetic patients and 67 dyslipidemia patients. They were classified as having MS or not (non-MS) according to the definition and diagnostic criteria of the MS proposed by the Japan Metabolic Syndrome Criteria Study Group in 2005 as previously described [9]. MS is defined as the presence of central adiposity (waist circumference of ≥ 85 cm for men and ≥ 90 cm for women) plus two or more of the following three criteria: 1) raised concentration Abstract. Little information on the relationship between blood rheology and atherosclerosis indicators in obese patients is available. We examined blood rheology as assessed by the blood passage time (BPT) with the microchannel method in 109 obese patients. BPT was correlated well with the extent of each metabolic syndrome component. A multivariate regression analysis revealed that the independent contributors to BPT were pulse-wave velocity, an index of arterial stiffness, body mass index and red blood cell. Furthermore, weight reduction intervention significantly decreased BPT. Assessment of rheology may be associated with pulse-wave velocity, and useful to manage obese patients. (Table 1). Conversely, independent PWV determinants were age (p<0.001), SBP (p<0.01) and BPT (p<0.01) (R 2 =0.467) ( Table 1).We examined effects of weight reduction therapy involving a 3-month of diet and exercise on BPT. We defined more than 3% of BW decrease as successful for weight reduction, and less than 3% as unsuccessful. While BPT significantly decreased in successful patients (n=10, 61.7 ± 7.7 → 48.7 ± 3.2sec, p< 0.05), BPT was unchanged throughout the treatment period in unsuccessful patients (n=29). The decrease of BPT by weight reduction was significantly related with the reduction of waist circumference (r=0.320, p<0.05), SBP (r=0.399, p<0.05) and PWV (r=0.422, p<0.01). DiscussionThe present study for the first time demonstrates that PWV, an index of atherosclerosis and a powerful CVD predictor, had a close relationship with BPT assessed by the microchannel method. In addition, BMI and RBC were the independent contributors to the increased BPT. Conversely, age, SBP and BPT were independent determinants of PWV. In particular, the results on the association between hemorheology/microcirculation and arterial stiffness may open a new track about a continuum or linkage on the systemic progression of atherosclerosis in obesity [6][7][8].Furthermore, the present interventional study demonstrated BPT significantly improved only in patients successful for weight reduction, concomitant wi...

High Blood Viscosity Is Closely Associated With Cigarette Smoking and Markedly Reduced by Smoking Cessation

“…3-5 We have also reported that blood viscosity increases markedly in patients with metabolic syndrome and decreases with weight reduction. 6 However, there has been no detailed analysis using the MC-FAN of reduced blood fluidity (ie, increased blood viscosity) in smokers. In this study, the BPT was significantly correlated with the number of cigarettes smoked per day, FTND score, and Brinkman index in patients who initially visited the Smoking Cessation Clinic.…”

“…The MC-FAN is superior to other methods in terms of accuracy and reproducibility, and evidence that it is markedly useful for the evaluation of blood fluidity and microcirculatory systems has accumulated. [4][5][6] Smoking is a major risk factor for cardiovascular diseases, associated with endothelial dysfunction, 7 but a decrease in blood fluidity in smokers or the effect of smoking cessation on viscosity has not yet been evaluated. Therefore, we measured blood fluidity in smokers, analyzed its correlation with various factors related to smoking, and examined whether quitting smoking improves fluidity.…”

Clinical Impact of Hemorheology Assessed Using the Microchannel Array Flow Analyzer on Renal Resistive Index in Patients With Type 2 Diabetes Mellitus

“…MC-FAN has a simple methodology and is superior to other methods regarding the accuracy of channel dimensions and high reproducibility. Furthermore, some clinical studies have reported a significant relationship between an increase in the whole blood passage time (WBPT), which is measured using MC-FAN, and cardiovascular risk factors or coronary artery disease [7][8][9][10][11].…”

The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method

“…Accordingly, it is crucial to elucidate the pathophysiology of CVD development in both disorders. Hemorheologic abnormalities are considered to be a possible contributor to the CVD formation in MetS (Kotani et al, 2007;Satoh et al, 2009) and CKD (Simpson et al, 1987).…”