Unexplained Pulmonary Hypertension Is Associated With Systolic Arterial Hypertension in Patients Undergoing Routine Doppler Echocardiographya

Finkelhor, Robert S.; Yang, Shawn; Bosich, Georgene; Bahler, Robert C.

doi:10.1378/chest.123.3.711

Cited by 5 publications

(7 citation statements)

References 15 publications

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“…Furthermore, men and women had similar resting and peak exercise RVSPs, despite the fact that men had significantly higher resting and peak exercise SBPs than women. Contrary to previous work investigating SBP and RVSP (16), our data indicate that SBP does not accurately predict the response of RVSP to exercise. However, when we differentiated the normal ExECHOs from the abnormal ExECHOs, a nonsignificant trend was found for a negative correlation between peak RVSP and peak SBP in patients with an abnormal ExECHO.…”

Section: Discussioncontrasting

confidence: 99%

“…Having shown here that RVSP increases with age, both at rest and peak exercise, and previous studies showing that resting RVSP increases with body mass index (16), further studies will be required to define the normal range of peak exercise RVSP according to body mass index. The relative lack of male compared with female patients reflects a local bias in performing routine exercise treadmill testing in male patients and exercise echocardiography in female patients.…”

Section: Discussionmentioning

confidence: 81%

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Estimated right ventricular systolic pressure during exercise stress echocardiography in patients with suspected coronary artery disease

Armstrong

Matangi

2010

Canadian Journal of Cardiology

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 81%

Estimated right ventricular systolic pressure during exercise stress echocardiography in patients with suspected coronary artery disease

Armstrong

Matangi

2010

Canadian Journal of Cardiology

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“…Some previously published studies reported the connection between systemic hypertension and elevated pulmonary pressures by echo (22). We could not confirm these results although we checked systolic, diastolic and mean arterial pressure for relation with PH.…”

Section: Discussionmentioning

confidence: 99%

Determinants of pulmonary hypertension in young adults

Guglin

Kolli

Ren

2012

International Journal of Clinical Practice

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“…The linear regression without intercept (Fig. 4) (10) This choice is not a correction for the numerical model, since it is able to reproduce clinical observations but is, rather, a better evaluation of the relationship between Q mv and Q mv .…”

Section: Resultsmentioning

confidence: 99%

Hemodynamic impact of mitral prosthesis-patient mismatch on pulmonary hypertension: an in silico study

Tanné¹,

Kadem²,

Rieu³

et al. 2008

Journal of Applied Physiology

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Recent clinical studies reported that prosthesis-patient mismatch (PPM) becomes clinically relevant when the effective orifice area (EOA) indexed by the body surface area (iEOA) is <1.2-1.25 cm(2)/m(2). To examine the effect of PPM on transmitral pressure gradient and left atrial (LA) and pulmonary arterial (PA) pressures and to validate the PPM cutoff values, we used a lumped model to compute instantaneous pressures, volumes, and flows into the left-sided heart and the pulmonary and systemic circulations. We simulated hemodynamic conditions at low cardiac output, at rest, and at three levels of exercise. The iEOA was varied from 0.44 to 1.67 cm(2)/m(2). We normalized the mean pressure gradient by the square of mean mitral flow indexed by the body surface area to determine at which cutoff values of iEOA the impact of PPM becomes hemodynamically significant. In vivo data were used to validate the numerical study, which shows that small values of iEOA (severe PPM) induce high PA pressure (residual PA hypertension) and contribute to its nonnormalization following a valve replacement, providing a justification for implementation of operative strategies to prevent PPM. Furthermore, we emphasize the major impact of pulmonary resistance and compliance on PA pressure. The model suggests also that the cutoff iEOA that should be used to define PPM at rest in the mitral position is approximately 1.16 cm(2)/m(2). At higher levels of exercise, the threshold for iEOA is rather close to 1.5 cm(2)/m(2). Severe PPM should be considered when iEOA is <0.94 cm(2)/m(2) at rest.

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Unexplained Pulmonary Hypertension Is Associated With Systolic Arterial Hypertension in Patients Undergoing Routine Doppler Echocardiographya

Cited by 5 publications

References 15 publications

Estimated right ventricular systolic pressure during exercise stress echocardiography in patients with suspected coronary artery disease

Estimated right ventricular systolic pressure during exercise stress echocardiography in patients with suspected coronary artery disease

Determinants of pulmonary hypertension in young adults

Hemodynamic impact of mitral prosthesis-patient mismatch on pulmonary hypertension: an in silico study

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