Unexplained postmenopausal uterine bleeding from atrophic endometrium: Histopathological and hormonal studies

Elkholi, Dina Gamal Eldeen Y.; Nagy, Halah Mohamed

doi:10.1016/j.mefs.2015.04.005

Cited by 7 publications

(7 citation statements)

References 28 publications

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“…This result is also consistent with numerous studies conducted across our country. [15][16][17][18][19][20] in which AUB was most common in peri-menopausal age group.…”

Section: Discussionmentioning

confidence: 99%

“…The study result is consistent with many other studies conducted across the globe, where fibroid uterus was the common condition associated with abnormal uterine bleeding. 12,20,21,[27][28][29] Unless uterine polyp, uterine fibroid develops during the reproductive age group, which would have contributed to the above finding, since majority of patients in this study were in the reproductive age group. Adenomyosis was the next common condition diagnosed by ultrasound which is also comparable with other studies.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between ultrasonographic and histopathological findings of hysterectomy specimen in patients with abnormal uterine bleeding

Mahajan¹,

Devi²,

Singh³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: AUB is a common and debilitating condition and it is one of the main gynaecological reasons for hysterectomy. Ultrasonography can be as good as histopathology (HPE) in the diagnosis of abnormal uterine bleeding. Hence, our study was conducted to validate the ultrasonographic findings with HPE findings in diagnosis of AUB.Methods: A hospital based cross-sectional analytical study was conducted among 86 patients with abnormal uterine bleeding in the department of Obstetrics and Gynaecology in collaboration with department of Pathology, RIMS, Imphal from September 2017 to March 2019. The clinical history and socio demographic profile were collected using a pre-designed proforma. General physical examination, pelvic examination and ultrasonagraphy was carried out and the hysterectomy specimens were subjected to histopathological examination.Results: Fibromyoma was diagnosed by ultrasound in 62.8% of the patients and it was the common diagnosis in this study. The sensitivity, specificity, positive predictive value, negative predictive value and kappa statistics of USG for diagnosing leiomyoma was 92.9%, 93.3%, 96.3%, 87.5% and 84.9% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and kappa statistics of USG for diagnosing adenomyosis was 53.8%, 98.6%, 87.5%, 92.3% and 62.3% respectively.Conclusions: The study provides an evidence that ultrasonography has good diagnostic accuracy as histopathology in the diagnosis of fibroid in patients with abnormal uterine bleeding. However, as with all the diagnostic procedures, the utility of ultrasound in the diagnosis of adenomyosis is questionable, since it has a low sensitivity amidst good specificity.

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“…This result is also consistent with numerous studies conducted across our country. [15][16][17][18][19][20] in which AUB was most common in peri-menopausal age group.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlation between ultrasonographic and histopathological findings of hysterectomy specimen in patients with abnormal uterine bleeding

Mahajan¹,

Devi²,

Singh³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Another theory suggests the rupture of thin-walled blood vessels around the cystically dilated atrophic glands as a possible cause. 23 The world literature also documents atrophic endometrium to be the most common cause of AUB in postmenopausal women. 24 Benign endometrial polyp.…”

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confidence: 99%

Pathological spectrum of endometrial biopsies in Saudi women with abnormal uterine bleeding

Husain

Hammad

Alduhaysh

et al. 2021

SMJ

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To assess and age stratify the types and frequencies of endometrial pathologies in Saudi women with abnormal uterine bleeding (AUB) that underwent endometrial biopsies, at our hospital over a 13-year period. Methods: In a retrospective study, from 2006 to 2018, all endometrial biopsies from Saudi women with AUB, reported at the laboratory of King Saud University-Medical City, Riyadh, Saudi Arabia, were revisited and analyzed. The women were categorized into <40, between 40-55 and >55 years of age. Original Article Results: We analyzed 6458 biopsies. In <40 and 40-55 years' groups cyclical endometrium was most common followed by endometrial polyps and disordered proliferative endometrium. In the >55 years' group, atrophic endometrium was most common followed by endometrial polyps. The hyperplasias and malignancies together accounted for 7.2% of the study, majority in the >55 years' group. Simple hyperplasia without atypia was the most common (3.9%), followed by malignancies (1.9%), complex atypical hyperplasia (0.7%), complex hyperplasia without atypia (0.4%), and simple atypical hyperplasia (0.3%). Conclusion: Awareness of the probable spectrum of endometrial histopathologies in the various ages is useful in guiding management. Endometrial biopsies are valuable in early detection of precancerous and cancerous endometrial lesions especially in women over 40 years.

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“…Similarly, the greater area and height of the endometrial glands from the O 3 group suggest a potential beneficial effect of O 3 gas on endometrial health. Considering that atrophic endometrium is a common age‐related lesion in women (Deeba et al., 2016; Elkholi & Nagy, 2015) and subfertile mares (Bracher et al, 1992), the potential regenerative properties of local O 3 therapy are worth investigating.…”

Section: Discussionmentioning

confidence: 99%

Endometrial angiogenesis induced by uterine insufflation with an oxygen–ozone gas mixture in mares

Ferreira

Amaral

Cardoso

et al. 2021

Reprod Domestic Animals

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Ozone (O3) therapy has been used to improve peripheral tissue oxygenation in humans and domestic animals. The goal of the present study was to characterize histological changes in the endometria of healthy equines following tissue exposure to gas mixtures enriched with different concentrations of O3. Cycling mares without endometrial degeneration were divided into three groups according to treatment (n = 9 mares/group). The uteri from the O3, ½O3 and control groups were insufflated for 3 min with gas containing 42, 21 and 0 μg O3 ml‐1, respectively. Treatments were performed every three days from D0 to D6. Endometrial samples were collected immediately before the first treatment and 24 hr after the last treatment. The following nine histological parameters were evaluated: (i) the number of endometrial blood vessels, (ii) endometrial vascular degree (EVD), (iii) increase rate of blood vessels, (iv) increase rate of EVD, (v) glandular total area, (vi) glandular lumen area, (vii) intraglandular secretion area, (viii) glandular epithelial height and (ix) luminal epithelial height. In the O3 group, a positive effect from treatment (p < .01) was detected for all vascular parameters (i, ii, iii and iv), glandular total area, intraglandular secretion area and glandular epithelial height. Compared to the control group, the ½O3 group had greater (p < .01) EVD (84.1 ± 12%) and a higher increase rate of blood vessels (151.9 ± 47.1%). Uterine insufflation with low or intermediate concentrations of the O2–O3 gas mixture induced endometrial angiogenesis. Morphometry, but not morphology, of the endometrial glands was affected by local O3 therapy. These findings would be of great significance for the development of new therapies for infertility in mares.

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Unexplained postmenopausal uterine bleeding from atrophic endometrium: Histopathological and hormonal studies

Cited by 7 publications

References 28 publications

Correlation between ultrasonographic and histopathological findings of hysterectomy specimen in patients with abnormal uterine bleeding

Correlation between ultrasonographic and histopathological findings of hysterectomy specimen in patients with abnormal uterine bleeding

Pathological spectrum of endometrial biopsies in Saudi women with abnormal uterine bleeding

Endometrial angiogenesis induced by uterine insufflation with an oxygen–ozone gas mixture in mares

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