Unexplained pancytopenia in acute myeloid leukemia treatment

Abstract

Key Clinical MessageCertain histopathological findings have been described in acute myeloid leukemia (AML) patients during treatment that define the hematologic outcomes. Such entities as bone marrow necrosis and hemophagocytic lymphohistiocytosis have been reported. These often result in severe pancytopenia.

Antioxidant Effect of Mouthwash Containing Zinc, Aloe Vera, and Stabilized Chlorine Dioxide for Oral Manifestation of Acute Myeloblastic Leukemia (Aml)

“…SCD releases oxygen to kill the anaerobic bacteria. It also has antiviral, anti-fungicidal, and antibacterial effects and maintains a normal pH in the oral cavity [13,24] The use of CD has made it possible to establish that 1) it is safe for local application without risk of systemic intoxication, 2) it does not intervene in the healing process, 3) it is effective even at low concentrations and 4) it does not generate antimicrobial resistance [14].…”

“…The most common chemotherapy-induced side effects can altered the conditions and functions of the mouth, including nausea, vomiting, fatigue, decreased appetite, changes in taste, and dry mouth, as well as gastrointestinal system [12]. Moreover, it often associated with early mortality [13]. The efficacy of AML therapy can be improved by the management of these side effects [12].…”