UNEXPLAINED JAUNDICE FOLLOWING NON-HALOTHANE ANAESTHESIA: A case Report

Hart, Stephanie; Fitzgerald, Peter

doi:10.1093/bja/47.12.1321

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Cited by 11 publications

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“…No case of hepatitis was discovered after anesthetics other than halothane, which is in agreement with most authors (6,15,19). Such cases are rare (7,20) and only one out of 144 cases of hepatotoxic drug reactions due to anesthetics, reported to the Danish Board of Adverse Reactions to Drugs, was attributed to nonhalothane anesthesia (8).…”

Section: Discussionsupporting

confidence: 82%

Halothane hepatitis in a prospective study of postoperative complications

Zaric

Larsen

Jacobsen

et al. 1986

Acta Anaesthesiol Scand

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In a prospective study comprising 2609 consecutive surgical patients, of whom 1166 were anesthetized with halothane, four cases of hepatitis were encountered. The incidence of hepatitis among those who received halothane was 1:292 in our material. The high incidence may be explained by the recognition of milder forms of hepatitis and by the selection of the series (over 40 years). Serum alanine aminotransferase should be investigated in all patients with postoperative pyrexia of unknown origin if mild forms of halothane hepatitis are to be discovered. The patient's history should be carefully examined for previous postoperative pyrexia of unknown origin following halothane anesthesia, in which case other anesthetics should be chosen.

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Section: Discussionsupporting

confidence: 82%