Unexplained infertility: Association with inherited thrombophilia

Fatini, C.; Conti, Lucia; Turillazzi, Valentina; Sticchi, Elena; Romagnuolo, Ilaria; Milanini, Maria Novella; Cozzi, C.; Abbate, Rosanna; Noci, Ivo

doi:10.1016/j.thromres.2012.02.012

Cited by 19 publications

(13 citation statements)

References 22 publications

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“…In spite of finding 2 cases with protein C deficiency in the unexplained infertility sample population and none in the control group, this difference failed to reach significance. This result is consistent with Fatini et al 2012 who studied the relationship between inherited thrombophilia and different causes of infertility, where 6 patients (2.6%) with unexplained infertility had protein C and s deficiency in comparison to 3 fertile women (1.2%) and the p value was 0.6 which was insignificant [19]. Another study found the incidence of protein C deficiency even more common in fertile women rather than women with unexplained infertility, yet; still the difference was statistically insignificant [9].…”

Section: Discussionsupporting

confidence: 92%

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Protein C Activity in Women With Unexplained Infertility

Sweed

Serag-Eldin

Wafa

2017

Journal of Advanced Medical Sciences and Applied Technologies

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Objectives:The relation between thrombophilia and infertility has drawn the attention in last few years. Most studies investigating the effect of inherited thrombophilia on infertility studied the relationship between thrombophilia and implantation failure. It was found to be a possible cause of impaired implantation in some subgroups of infertile women. Still thrombophilia screening in general infertile population is unjustified and in fact may lead to increased patient anxiety after a positive test result together with the increased cost. Due to the poor information available concerning the relationship between inherited thrombophilia and infertility, we performed a case-control study in order to evaluate the prevalence of protein C activity in women with unexplained infertility.

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Section: Discussionsupporting

confidence: 92%

“…Still this pilot study included limited number of participants and didn't investigate other thrombophilia markers to assess their relation with unexplained infertility, especially that others have demonstrated the relationship between other inherited thrombophilia markers and unexplained infertility [19]. Data are presented as number (%).…”

Section: Resultsmentioning

confidence: 99%

Protein C Activity in Women With Unexplained Infertility

Sweed

Serag-Eldin

Wafa

2017

Journal of Advanced Medical Sciences and Applied Technologies

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“…The crucial effects of thrombophilic disorders on conception and pregnancy outcome have been addressed properly in previous investigations[16]–[21]. Fatini et al demonstrated that a significant relationship between inherited thrombophilia and unexplained infertility in 930 infertile females of Caucasian origin, thus suggesting the contribution of genetic components in modulating unexplained infertility[22]. Thus, several subfertile women cases in Gaza could be therapeutically managed by correcting or adjusting their coagulation profile before and during the childbearing period.…”

Section: Discussionmentioning

confidence: 99%

Etiological risk factors for subfertility among Palestinian women in Gaza

Sirdah

Abushahla²,

Ghalayeni³

et al. 2013

J Biomed Res

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The inability to procreate is frequently considered a personal tragedy and a hardship for couples, impacting on the entire family and even the local community. In Gaza strip, Palestine, there has been no study on etiological risk factors for subfertility. The present study aimed to identify risk factors associated with subfertility among women in Gaza, Palestine. One hundred and sixty-nine women in the study group and 115 women in the control group were included. Cases were selected randomly from those referred to the Al Basma Fertility Center, Gaza, Palestine. Data were collected through close-ended questionnaire, sonography, hormonal analysis and thrombophilia profile that included the methylenetetrahydrofolate reductase (MTHFR 677 C > T), factor V leiden (1691 G > A) and prothrombin (20210 G > A) genes. By using univariate analyses, the effects of different patient-related variables on the presence of subfertility were evaluated. A multiple logistic regression model was constructed, crude and adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were calculated. The findings showed that 73.5 % (169/230) of the women referred to the Al Basma Center sought treatment for subfertility. Different etiological risk factors were associated with subfertility, the most frequent of which in descending order were: thrombophilic disorders, fallopian tube problems, sex hormone abnormalities and polycystic ovary syndrome with an adjusted OR of 21.42, 13.63, 11.69 and 10.29, respectively. In conclusion, several etiological risk factors are responsible for subfertility among women in Gaza. Comprehensive evaluation of infertile women should be considered in the course of treatment; otherwise, the duration of sterility may be extended.

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“…A case-control study including 930 patients evaluated the presence of thrombophilia in patients with unexplained infertility, and showed that the odds of inherited thrombophilia was 1.97 significantly higher in patients with unexplained infertility than in the control group suggesting a contribution of thrombophilia by the same mechanism to repeated IVF failures [47]. Two years later, Safdarian matched 96 cases with RIF to controls in which RIF was defined as failure to achieve pregnancy following 2 -6 IVF cycles where more than 10 high grade embryos transferred into the uterus [48], showed that having at least one inherited thrombophilia is a risk factor for recurrent failure.…”

Section: Thrombophilia and Ivfmentioning

confidence: 99%

Recurrent Implantation Failure and Low Molecular Weight Heparin

Khalife¹,

Ghazeeri²

2018

OJOG

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Implantation of the embryo into the endometrium is the first step in the establishment of pregnancy. This process is complex, and depends on many factors. Recurrent implantation failure is a source of distress to patients and specialists. It is defined as failure to achieve a viable pregnancy, following ">3 embryo transfers with high quality embryos or the transfer of ≥ 10 embryos in multiple transfers". Thrombophilic conditions that contribute to recurrent implantation failure are the main concern in this review. The mechanism of implantation failure is believed to be due to decreased blood flow to the endometrium and placenta which can hinder normal endometrial receptivity leading to miscarriage. Defects in early placentation resulting in pregnancy failure, have focused attention on the therapeutic potential of low molecular weight heparin in the implantation process. Heparin has a role at all stages of implantation to improve pregnancy outcomes. There are controversies in literature regarding the association between thrombophilia and recurrent implantation failure and available literature regarding this issue is very heterogeneous. Various investigators, have shown that women with RIF are more likely to have a thrombophilia disorder, yet a clear cause cannot be acknowledged from these studies. Heparin treatment has been evaluated in several studies, showing conflicting evidence. However, several studies have pointed out that it may play a role in a subset of patients who presents a thrombophilia mutation, thus the group of patients that might benefit is needed to be identified. This review is dedicated to evaluate the published literature about the role of low molecular weight heparin in case of recurrent implantation failure with or without the presence of thrombophilia.

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Unexplained infertility: Association with inherited thrombophilia

Cited by 19 publications

References 22 publications

Protein C Activity in Women With Unexplained Infertility

Protein C Activity in Women With Unexplained Infertility

Etiological risk factors for subfertility among Palestinian women in Gaza

Recurrent Implantation Failure and Low Molecular Weight Heparin

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