Unexplained gastrointestinal dysmotility: the clue may lie in the brain

Parry‐Jones, Adrian; Paine, Peter; Ramdass, Ranjit; Townsend, Neal; Hammonds, Richard; Teubner, Antje; Shaffer, Jon; Cooper, Paul R.; Lal, Simon

doi:10.1136/gut.2009.202465

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Diseases of the central and peripheral nervous system can affect the motility of the gastrointestinal system, and at the most extreme end of the spectrum, can result in PIPO (84,132,162,227,228).…”

Section: 7: Neurological Evaluationmentioning

confidence: 99%

Paediatric Intestinal Pseudo‐obstruction

Thapar

Saliakellis

Benninga

et al. 2018

J. pediatr. gastroenterol. nutr.

115

224

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Section: 7: Neurological Evaluationmentioning

confidence: 99%

Paediatric Intestinal Pseudo‐obstruction

Thapar

Saliakellis

Benninga

et al. 2018

J. pediatr. gastroenterol. nutr.

115

224

View full text Add to dashboard Cite

show abstract

“…Muscular dystrophies, polymyositis, mitochondriopathies, Parkinson's disease, multiple sclerosis, myasthenia gravis, syringomyelia and Guillain‐Barré syndrome can all also present with severe dysmotility . Indeed, dysmotility is a cardinal manifestation of several mitochondrial diseases, such as mitochondrial neurogastrointestinal encephalomyopathy, mitochondrial DNA depletion syndrome, Alpers’ syndrome, Pearson syndrome, mitochondrial encephalomyopathy, lactic acidosis, and stroke (MELAS), and polyneuropathy, ophthalmoplegia, leucoencephalopathy, and intestinal pseudo‐obstruction (POLIP) syndrome …”

Section: Classification Aetiology and Clinical Presentationsmentioning

confidence: 99%

“…Disadvantages include expense and availability of expertise. MR brain may be useful to exclude pituitary tumours and in the assessment of mitochondriopathies where white matter changes may be seen …”

Section: Classification Aetiology and Clinical Presentationsmentioning

confidence: 99%

Review article: the assessment and management of chronic severe gastrointestinal dysmotility in adults

Paine

McLaughlin

Lal

2013

Aliment Pharmacol Ther

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“…27,28 There are also rare conditions such as mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) associated with weight loss and dysmotility symptoms. 29 This is why we hypothesized weight loss would be found in association with dysmotility symptoms. Univariately, both weight gain and weight loss were linked to symptoms of nausea and/or vomiting, but after adjusting for confounders this was not statistically significant.…”

mentioning

confidence: 97%

Dysmotility Symptoms Are Independently Associated With Weight Change: A Population-based Study of Australian Adults

Eslick

Howell

Talley

2015

J Neurogastroenterol Motil

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Background/AimsWeight loss is a recognized alarm symptom for organic gastrointestinal (GI) disease, yet the association between weight change (loss or gain) and specific GI symptoms remains poorly described. We assess the associations between GI symptoms and weight change in a population-based sample of Australian adults.MethodsThe prevalence of 26 GI symptoms was determined by a postal survey to 5000 residents in western Sydney, Australia (60% response rate). These were classified a priori into 5 symptom groups–abdominal pain, esophageal symptoms, dysmotility symptoms, diarrhea and constipation. Weight change was measured by two items which assessed weight loss and weight gain. Clinically relevant weight change was defined as a loss or gain of 3 or more kilograms in the past 3 months.ResultsPrevalence estimates for clinically relevant weight loss and gain in the past 3 months were 10.3% and 8.1%, respectively. When the 5 symptom groups were evaluated simultaneously, the dysmotility symptoms of fullness after meals emerged as a predictor of both weight loss (OR, 1.57; 95% CI, 1.32–1.88; P < 0.001) and weight gain (OR, 0.85; 95% CI, 0.72–0.99; P = 0.040), which also included bloating (OR, 1.64; 95% CI 1.46–1.84; P < 0.001). The associations remained significant following adjustment for socio-economic status, body mass index, and eating behaviors.ConclusionsSpecific dysmotility symptoms are independently predictive of both weight loss and weight gain. Different pathogenic mechanisms may be involved.

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Unexplained gastrointestinal dysmotility: the clue may lie in the brain

Cited by 4 publications

References 9 publications

Paediatric Intestinal Pseudo‐obstruction

Paediatric Intestinal Pseudo‐obstruction

Review article: the assessment and management of chronic severe gastrointestinal dysmotility in adults

Dysmotility Symptoms Are Independently Associated With Weight Change: A Population-based Study of Australian Adults

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