Background-The de novo occurrence of sustained ventricular tachycardia (VT) after CABG has been described, but the incidence, mortality rate, long-term follow-up, and mechanism are not well defined. Methods and Results-This prospective study enrolled consecutive patients undergoing CABG at a single institution.Patients were followed up for the development of sustained VT, and a detailed analysis of clinical, angiographic, and surgical variables associated with the occurrence of VT was performed. A total of 382 patients participated, and 12 patients (3.1%) experienced Ն1 episode of sustained VT 4.1Ϯ4.8 days after CABG. In 11 of 12 patients, no postoperative complication explained the VT; 1 patient had a perioperative myocardial infarction. The in-hospital mortality rate was 25%. Patients with VT were more likely to have prior myocardial infarction (92% versus 50%, PϽ0.01), severe congestive heart failure (56% versus 21%, PϽ0.01), and ejection fraction Ͻ0.40 (70% versus 29%, PϽ0.01). When all 3 factors were present, the risk of VT was 30%, a 14-fold increase. Patients with VT had more noncollateralized totally occluded vessels on angiogram (1.4Ϯ0.97 versus 0.54Ϯ0.7, PϽ0.01), a bypass graft across a noncollateralized occluded vessel (1.50Ϯ1.0 versus 0.42Ϯ0.62, PϽ0.01), and a bypass graft across a noncollateralized occluded vessel to an infarct zone (1.50Ϯ1.0 versus 0.17Ϯ0.38, PϽ0.01). By multivariate analysis, the number of bypass grafts across a noncollateralized occluded vessel to an infarct zone was the only independent factor predicting VT. Conclusions-The first presentation of sustained monomorphic VT in the recovery period after CABG is uncommon, but the incidence is high in specific clinical subsets. Placement of a bypass graft across a noncollateralized total occlusion in a vessel supplying an infarct zone was strongly and independently associated with the development of VT. (Circulation. 1999;99:903-908.)