Unexpected Rule-Changes in a Working Memory Task Shape the Firing of Histologically Identified Delay-Tuned Neurons in the Prefrontal Cortex

Ozdemir, A. Tugrul; Lagler, Michael; Lagoun, Sabria; Malagon‐Vina, Hugo; Lasztóczi, Bálint; Klausberger, Thomas

doi:10.1016/j.celrep.2019.12.102

Cited by 9 publications

(9 citation statements)

References 63 publications

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“…This is similar to (26), and is reminiscent of previous works, where remapping occured after learning in spite of environmental and contextual cues remaining the same (49,67). The mPFC, at a population level, did not show significant changes in spatial firing propensity for different rules, in apparent contrast with other studies (38)(39)(40)(41)(42)(43)(44). This discrepancy might be explained by the fact that in some of these studies the behavioural tasks were different.…”

Section: Stability Of Couplings Across Rules It Has Previously Beencontrasting

confidence: 83%

“…Spatial coding across rules. It has been shown that mPFC firing changes during rule-switching tasks (38)(39)(40)(41)(42)(43)(44), suggesting that this area encodes information about the rule or the insight that the rule has changed. Conversely, the hippocampus is well-known for its ability of changing firing characteristics in response to environmental and contextual changes (45)(46)(47).…”

Section: Potential Mechanisms Of Spatial Information Transfer Andmentioning

confidence: 99%

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The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus

Nardin

Kaefer

Csicsvari

2021

Preprint

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Hippocampal and neocortical neural activity is modulated by the position of the individual in space. While hippocampal neurons provide the basis for a spatial map, prefrontal cortical neurons generalize over environmental features. Whether these generalized representations result from a bidirectional interaction with, or are mainly derived from hippocampal spatial representations is not known. By examining simultaneously recorded hippocampal and medial prefrontal neurons, we observed that prefrontal spatial representations show a delayed coherence with hippocampal ones. We also identified subpopulations of cells in the hippocampus and medial prefrontal cortex that formed functional cross-area couplings; these resembled the optimal connections predicted by a probabilistic model of spatial information transfer and generalization. Moreover, cross-area couplings were strongest and had the shortest delay preceding spatial decision-making. Our results suggest that generalized spatial coding in the medial prefrontal cortex is inherited from spatial representations in the hippocampus, and that the routing of information can change dynamically with behavioral demands.

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Section: Stability Of Couplings Across Rules It Has Previously Beencontrasting

confidence: 83%

Section: Potential Mechanisms Of Spatial Information Transfer Andmentioning

confidence: 99%

The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus

Nardin

Kaefer

Csicsvari

2021

Preprint

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“…It must be noted that rodent models are commonly used to study short-term memory and delay activity has been reported in areas associated with rodent cognition, in particular the medial prefrontal cortex (Park et al, 2019;Ozdemir et al, 2020). Although experiments using rodent models have enriched our understanding of short-term memory mechanisms, the rodent visual system diverges from that of primates: rodents lack a granular prefrontal cortex making the comparison with primate brain regions problematic (Uylings et al, 2003;Passingham and Wise, 2012).…”

Section: Croxson Et Al (2011) Macaca Mulattamentioning

confidence: 99%

Neural Substrates of Visual Perception and Working Memory: Two Sides of the Same Coin or Two Different Coins?

Roussy

Mendoza-Halliday

Martinez‐Trujillo

2021

Front. Neural Circuits

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Visual perception occurs when a set of physical signals emanating from the environment enter the visual system and the brain interprets such signals as a percept. Visual working memory occurs when the brain produces and maintains a mental representation of a percept while the physical signals corresponding to that percept are not available. Early studies in humans and non-human primates demonstrated that lesions of the prefrontal cortex impair performance during visual working memory tasks but not during perceptual tasks. These studies attributed a fundamental role in working memory and a lesser role in visual perception to the prefrontal cortex. Indeed, single cell recording studies have found that neurons in the lateral prefrontal cortex of macaques encode working memory representations via persistent firing, validating the results of lesion studies. However, other studies have reported that neurons in some areas of the parietal and temporal lobe—classically associated with visual perception—similarly encode working memory representations via persistent firing. This prompted a line of enquiry about the role of the prefrontal and other associative cortices in working memory and perception. Here, we review evidence from single neuron studies in macaque monkeys examining working memory representations across different areas of the visual hierarchy and link them to studies examining the role of the same areas in visual perception. We conclude that neurons in early visual areas of both ventral (V1-V2-V4) and dorsal (V1-V3-MT) visual pathways of macaques mainly encode perceptual signals. On the other hand, areas downstream from V4 and MT contain subpopulations of neurons that encode both perceptual and/or working memory signals. Differences in cortical architecture (neuronal types, layer composition, and synaptic density and distribution) may be linked to the differential encoding of perceptual and working memory signals between early visual areas and higher association areas.

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“…There were no performance deficits at the short delay (30 s delay); however, the choice accuracy significantly decreased in the D group as the delay was extended (60 s delay). Prefrontal activity during the delay period is more important in memory retention than in inhibitory control or decision-making [45,46]. The impaired prefrontal cortex is capable of completing the correct choice at a short delay using an alternate strategy, while it exhibits a poor accuracy at longer delays as working memory demands increase [44,47].…”

Section: Discussionmentioning

confidence: 99%

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

Wang

Lin

Lee

et al. 2020

IJMS

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Early-life exposure to di-(2-ethylhexyl)-phthalate (DEHP) has been suggested to relate to hyperactivity, lack of attention, and working memory deficits in school-age children. Brain-derived neurotrophic factor (BDNF) and endocannabinoids are induced by aerobic exercises to provide beneficial effects on brain functions. This study investigated the mechanisms underlying working memory impairment and the protective role of exercise in prenatal DEHP-exposed male rats. Sprague Dawley dams were fed with vehicle or DEHP during gestation. The male offspring were trained to exercise on a treadmill for 5 weeks, which was followed by an assessment of their working memory with a T-maze delayed non-match-to-sample task. The expressions of BDNF, dopamine D1 receptor (D1R), cannabinoid receptor 1 (CB1R), and fatty acid amide hydrolase (FAAH) in the prefrontal cortex were detected by Western blot. The results showed that DEHP-exposed rats exhibited working memory impairments without significant alterations in locomotor activities. The reduced expressions of prefrontal BDNF and CB1R were obtained in the DEHP-exposed rats, while D1R and FAAH were barely affected. Importantly, aerobic exercise during childhood-adolescence prevented the impairment of working memory in the DEHP-exposed rats by recovering the BDNF and CB1R expressions in the prefrontal cortex. These findings suggest that exercise may provide beneficial effects in ameliorating the impairment of working memory in the prenatal DEHP-exposed male rats at late adolescence.

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Unexpected Rule-Changes in a Working Memory Task Shape the Firing of Histologically Identified Delay-Tuned Neurons in the Prefrontal Cortex

Cited by 9 publications

References 63 publications

The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus

The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus

Neural Substrates of Visual Perception and Working Memory: Two Sides of the Same Coin or Two Different Coins?

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

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