“…Before the early 2000s, only about 100 cases of persistent pruritic nodules after vaccination with aluminum‐absorbed vaccines had been reported . In addition to long‐lasting, pruritic nodules at the injection site, other commonly documented symptoms include excoriations, eczema, hyperpigmentation, hypopigmentation, hypertrichosis, and infiltration . These nodules have been reported to have several distinct histologic patterns, including subcutaneous collections of histiocytes, subcutaneous mononuclear inflammatory cell infiltrates with eosinophils and germinal center formation, and deep granuloma annulare–like infiltrates with surrounding dense collections of macrophages .…”