Unexpected long-term survival in a BRCA2 patient with metastatic carcinosarcoma associated with tamoxifen

Abstract

► This report concerns a long survival of a BRCA2 patient with a relapsing uterine carcinosarcoma. ► Rarity of long survivorship in relapsing carcinosarcoma is confirmed by literature review. ► BRCA2 status plus platinum-hypersensitivity as contributors for the favorable outcome, even if carcinosarcoma doesn't belong to the BRCA1/2 phenotype.

P53 and SOX2 Protein Expression Predicts Esophageal Adenocarcinoma in Response to Neoadjuvant Chemoradiotherapy

“…[14][15][16] However, there is no general consensus on the predictive value of p53 status for therapy response. Other potential biomarkers are SOX2 and CD44, both linked to cancer stem cells (CSCs), a small population of cells, found to be more resistant to chemotherapy and radiotherapy in various malignant tumor types.…”